Abstract
It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish larvae that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa. Sodium channel knock-down promotes migration of differentiated sensory neurons away from the ganglia. Once in a new environment, sensory neurons transdifferentiate regardless of sodium channel expression. These findings reveal an unsuspected plasticity in differentiated neurons that points to new strategies for treatment of nervous system disease.
Original language | English (US) |
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Pages (from-to) | 3047-3056 |
Number of pages | 10 |
Journal | Development |
Volume | 137 |
Issue number | 18 |
DOIs | |
State | Published - Sep 15 2010 |
Keywords
- Dorsal root ganglia neurons
- Nav1.6
- Transdifferentiation
- Zebrafish
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology