In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

L. Steinman, J. T. Rosenbaum, S. Sriram, H. O. McDevitt

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Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

Original languageEnglish (US)
Pages (from-to)7111-7114
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number11
DOIs
StatePublished - Nov 1981

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