In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

L. Steinman; J. T. Rosenbaum; S. Sriram; H. O. McDevitt

doi:10.1073/pnas.78.11.7111

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

L. Steinman, J. T. Rosenbaum, S. Sriram, H. O. McDevitt

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Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

Original language	English (US)
Pages (from-to)	7111-7114
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	78
Issue number	11
DOIs	https://doi.org/10.1073/pnas.78.11.7111
State	Published - Nov 1981
Externally published	Yes

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abstract = "Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.",

author = "L. Steinman and Rosenbaum, {J. T.} and S. Sriram and McDevitt, {H. O.}",

year = "1981",

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AU - Sriram, S.

AU - McDevitt, H. O.

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AB - Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

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In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

Abstract

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