In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

L. Steinman, James (Jim) Rosenbaum, S. Sriram, H. O. McDevitt

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203 Citations (Scopus)

Abstract

Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

Original languageEnglish (US)
Pages (from-to)7111-7114
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number11
StatePublished - Nov 1981
Externally publishedYes

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Encephalitis
Immunization
Spinal Cord
Antigens
Antibodies
Genes
Immune Sera

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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abstract = "Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.",
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AU - Sriram, S.

AU - McDevitt, H. O.

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N2 - Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord antigen. No protection was evident in animals that received antisera specific for I-Js gene products. Administration of antibody to I-As beginning 5 days after immunization with spinal cord antigen delayed, but did not prevent, the onset of experimental allergic encephalitis.

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