In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

Jiechen Yin, Gangjun Liu, Jun Zhang, Lingfeng Yu, Sari Mahon, David Mukai, Matthew Brenner, Zhongping Chen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report on the feasibility of rapid, highresolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/ s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on the comprehensive 3-D volumetric data.

Original languageEnglish (US)
Article number060503
JournalJournal of Biomedical Optics
Volume14
Issue number6
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Optical tomography
smoke
Smoke
tomography
endoscopes
Endoscopy
circumferences
ventilation
rabbits
respiration
Parallel processing systems
Ventilation
microelectromechanical systems
MEMS
image processing
artifacts
Image processing
Display devices
Scanning
scanning

Keywords

  • 3-Dimensional imaging
  • Image processing
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography. / Yin, Jiechen; Liu, Gangjun; Zhang, Jun; Yu, Lingfeng; Mahon, Sari; Mukai, David; Brenner, Matthew; Chen, Zhongping.

In: Journal of Biomedical Optics, Vol. 14, No. 6, 060503, 2009.

Research output: Contribution to journalArticle

Yin, Jiechen ; Liu, Gangjun ; Zhang, Jun ; Yu, Lingfeng ; Mahon, Sari ; Mukai, David ; Brenner, Matthew ; Chen, Zhongping. / In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography. In: Journal of Biomedical Optics. 2009 ; Vol. 14, No. 6.
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