In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy

T. R. Henry, K. A. Frey, J. C. Sackellares, S. Gilman, R. A. Koeppe, J. A. Brunberg, Donald (Don) Ross, S. Berent, A. B. Young, D. E. Kuhl

Research output: Contribution to journalArticle

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Abstract

Positron emission tomography measured interictal cerebral glucose metabolism with [18F]fluorodeoxyglucose and central benzodiazepine-receptor binding with [11C]fluniazenil in 10 mesial temporal lobe epilepsy (TLE) patients and in normal subjects. Eight TLE patients had mesial temporal, lateral temporal, and thalamic hypometabolism ipsilateral to EEG ictal onsets, with additional extratemporal hypometabolism in four. One had unilateral anterior mesial temporal hypometabolism only, and one had normal metabolism. Each patient had decreased benzodiazepine-receptor binding in the ipsilateral anterior mesial temporal region, without neocortical changes. Thus, interictal metabolic dysfunction is variable and usually extensive in TLE, whereas decreased central benzodiazepine-receptor density is more restricted to mesial temporal areas. Metabolic patterns in TLE may reflect diaschisis, while benzodiazepine-receptor changes may reflect localized neuronal and synaptic loss that is specific to the epileptogenic zone. [11C]Flumazenil imaging may be useful in presurgical evaluation of refractory complex partial seizures.

Original languageEnglish (US)
Pages (from-to)1998-2006
Number of pages9
JournalNeurology
Volume43
Issue number10
StatePublished - Oct 1993
Externally publishedYes

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Temporal Lobe Epilepsy
GABA-A Receptors
Flumazenil
Fluorodeoxyglucose F18
Temporal Lobe
Positron-Emission Tomography
Electroencephalography
Seizures
Stroke
Glucose
Metabolism
Benzodiazepines

ASJC Scopus subject areas

  • Neuroscience(all)
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Henry, T. R., Frey, K. A., Sackellares, J. C., Gilman, S., Koeppe, R. A., Brunberg, J. A., ... Kuhl, D. E. (1993). In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. Neurology, 43(10), 1998-2006.

In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. / Henry, T. R.; Frey, K. A.; Sackellares, J. C.; Gilman, S.; Koeppe, R. A.; Brunberg, J. A.; Ross, Donald (Don); Berent, S.; Young, A. B.; Kuhl, D. E.

In: Neurology, Vol. 43, No. 10, 10.1993, p. 1998-2006.

Research output: Contribution to journalArticle

Henry, TR, Frey, KA, Sackellares, JC, Gilman, S, Koeppe, RA, Brunberg, JA, Ross, DD, Berent, S, Young, AB & Kuhl, DE 1993, 'In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy', Neurology, vol. 43, no. 10, pp. 1998-2006.
Henry TR, Frey KA, Sackellares JC, Gilman S, Koeppe RA, Brunberg JA et al. In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. Neurology. 1993 Oct;43(10):1998-2006.
Henry, T. R. ; Frey, K. A. ; Sackellares, J. C. ; Gilman, S. ; Koeppe, R. A. ; Brunberg, J. A. ; Ross, Donald (Don) ; Berent, S. ; Young, A. B. ; Kuhl, D. E. / In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. In: Neurology. 1993 ; Vol. 43, No. 10. pp. 1998-2006.
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