In vitro radiosensitivity of fibroblasts derived from patients with retinoblastoma and abnormalities of chromosome 13

Ralph R. Weichselbaum, Warren W. Nichols, Daniel Albert

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In vitro x-ray survival experiments were performed on fibroblast strains derived from nine patients with sporatic unilateral retinoblastoma and 26 patients with hereditary retinoblastoma. Fibroblasts derived from patients with hereditary retinoblastoma were significantly more radiosensitive than those derived from patients with sporatic retinoblastoma. The authors hypothesize that the increased in vitro radio-sensitivity observed in some hereditary retinoblastoma cell strains is a reflection of an, as yet, uncharacterized defect in DNA repair or post-irradiation DNA replication. X-ray sensitivity was also measured in 19 fibroblast strains derived from patients bearing deletions, trisomies, inversions, or translocations of all or part of chromosome 13. These results are compared with data from individuals trisomic for three other autosomes. The results suggest an association between abnormalities of chromosome 13 and the cytotoxic effects of x-irradiation.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
JournalRetina
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 13
Retinoblastoma
Radiation Tolerance
Fibroblasts
X-Rays
Trisomy
DNA Replication
Radio
DNA Repair
In Vitro Techniques
Survival

Keywords

  • Chromosome 13
  • D-deletion syndrome
  • Radiosensitivity
  • Retinoblastoma
  • Trisomy
  • X-irradiation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

In vitro radiosensitivity of fibroblasts derived from patients with retinoblastoma and abnormalities of chromosome 13. / Weichselbaum, Ralph R.; Nichols, Warren W.; Albert, Daniel.

In: Retina, Vol. 3, No. 2, 01.01.1983, p. 126-130.

Research output: Contribution to journalArticle

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