Abstract
In vitro fertilization (IVF) in the older patient presents a significant challenge to the clinician. Older IVF patients have higher cancellation rates, lower oocyte yields, lower pregnancy rates, and higher miscarriage rates, despite significant improvements in IVF success rates in the past decade. Markers of diminished ovarian reserve, including basal follicle-stimulating hormone and estradiol levels, clomiphene citrate challenge test, inhibin B, müllerian-inhibiting substance, ovarian volume, and antral follicle counts, can be useful in counseling patients. Alterations in the stimulation protocol, such as changing the gonadotropin or gonadotropin-releasing hormone (GnRH) agonist dose, use of the agonist flare or microdose flare protocols, or use of a GnRH antagonist have met with varying degrees of success in improving outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-383 |
| Number of pages | 9 |
| Journal | Current Women's Health Reports |
| Volume | 3 |
| Issue number | 5 |
| State | Published - Oct 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
In vitro fertilization in the older patient. / Derman, Seth G.; Seifer, David.
In: Current Women's Health Reports, Vol. 3, No. 5, 10.2003, p. 375-383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro fertilization in the older patient
AU - Derman, Seth G.
AU - Seifer, David
PY - 2003/10
Y1 - 2003/10
N2 - In vitro fertilization (IVF) in the older patient presents a significant challenge to the clinician. Older IVF patients have higher cancellation rates, lower oocyte yields, lower pregnancy rates, and higher miscarriage rates, despite significant improvements in IVF success rates in the past decade. Markers of diminished ovarian reserve, including basal follicle-stimulating hormone and estradiol levels, clomiphene citrate challenge test, inhibin B, müllerian-inhibiting substance, ovarian volume, and antral follicle counts, can be useful in counseling patients. Alterations in the stimulation protocol, such as changing the gonadotropin or gonadotropin-releasing hormone (GnRH) agonist dose, use of the agonist flare or microdose flare protocols, or use of a GnRH antagonist have met with varying degrees of success in improving outcomes.
AB - In vitro fertilization (IVF) in the older patient presents a significant challenge to the clinician. Older IVF patients have higher cancellation rates, lower oocyte yields, lower pregnancy rates, and higher miscarriage rates, despite significant improvements in IVF success rates in the past decade. Markers of diminished ovarian reserve, including basal follicle-stimulating hormone and estradiol levels, clomiphene citrate challenge test, inhibin B, müllerian-inhibiting substance, ovarian volume, and antral follicle counts, can be useful in counseling patients. Alterations in the stimulation protocol, such as changing the gonadotropin or gonadotropin-releasing hormone (GnRH) agonist dose, use of the agonist flare or microdose flare protocols, or use of a GnRH antagonist have met with varying degrees of success in improving outcomes.
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UR - http://www.scopus.com/inward/citedby.url?scp=1542568314&partnerID=8YFLogxK
M3 - Article
C2 - 12959695
AN - SCOPUS:1542568314
VL - 3
SP - 375
EP - 383
JO - Current Women's Health Reports
JF - Current Women's Health Reports
SN - 1534-5874
IS - 5
ER -