In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins

R. K. Goel, K. Sairam, M. Dora Babu, I. A. Tavares, Amala Soumyanath

29 Scopus citations

Abstract

Bacopa monniera is an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of Bacopa monniera (BME) in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized BME (bacoside A content - 35.5 ± 0.9) on other contributing factors towards ulcerogenesis. BME in the dose of 1000 μg/ml showed anti-Helicobacter pylori activity in vitro I and in the dose of 10 μg/ml increased in vitro of prostanoids (PGE and PGI2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of BME.

Original languageEnglish (US)
Pages (from-to)523-527
Number of pages5
JournalPhytomedicine
Volume10
Issue number6-7
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Antiulcerogenic
  • Bacopa monniera
  • Bacoside-A
  • Gastric mucosal offensive and defensive factors
  • Helicobacter pylori
  • Prostaglandins

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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