In vitro effects of ethanol on primate luteal membranes: Exposure of additional gonadotropin receptor sites

Judy L. Cameron, Richard L. Stouffer

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    The presence of 0.8–8.0% (vol/vol) ethanol increased the specific binding of [125I]human luteinizing hormone (hLH) to membrane particulate fractions prepared from the rhesus monkey corpus luteum in a dose-dependent manner. Ethanol increased the number of available gonadotropin binding sites without altering their affinity for LH. These results suggest that (1) there are additional gonadotropin receptors in the macaque corpus luteum which are not detected by conventional in vitro techniques, and (2) ethanol exposes receptors previously unavailable for hormone interaction.

    Original languageEnglish (US)
    Pages (from-to)1451-1453
    Number of pages3
    JournalEndocrinology
    Volume110
    Issue number4
    DOIs
    StatePublished - Apr 1982

    ASJC Scopus subject areas

    • Endocrinology

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