In Utero Life and Epigenetic Predisposition for Disease

Research output: Book/ReportBook

53 Citations (Scopus)

Abstract

Regulatory regions of the human genome can be modified through epigenetic processes during prenatal life to make an individual more likely to suffer chronic diseases when they reach adulthood. The modification of chromatin and DNA contributes to a larger well-documented process known as "programming" whereby stressors in the womb give rise to adult onset diseases, including cancer. It is now well known that death from ischemic heart disease is related to birth weight; the lower the birth weight, the higher the risk of death from cardiovascular disease as well as type 2 diabetes and osteoporosis. Recent epidemiological data link rapid growth in the womb to metabolic disease and obesity and also to breast and lung cancers. There is increasing evidence that "marked" regions of DNA can become "unmarked" under the influence of dietary nutrients. This gives hope for reversing propensities for cancers and other diseases that were acquired in the womb. For several cancers, the size and shape of the placenta are associated with a person's cardiovascular and cancer risks as are maternal body mass index and height. The features of placental growth and nutrient transport properties that lead to adult disease have been little studied. In conclusion, several cancers have their origins in the womb, including lung and breast cancer. More research is needed to determine the epigenetic processes that underlie the programming of these diseases.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages21
Volume71
EditionC
DOIs
StatePublished - 2010

Publication series

NameAdvances in Genetics
No.C
Volume71
ISSN (Print)00652660

Fingerprint

Epigenomics
Genetic Epigenesis
Neoplasms
Birth Weight
Lung Neoplasms
Breast Neoplasms
Food
Nucleic Acid Regulatory Sequences
DNA
Metabolic Diseases
Human Genome
Growth
Type 2 Diabetes Mellitus
Placenta
Osteoporosis
Chromatin
Myocardial Ischemia
Body Mass Index
Chronic Disease
Cardiovascular Diseases

ASJC Scopus subject areas

  • Genetics

Cite this

In Utero Life and Epigenetic Predisposition for Disease. / Thornburg, Kent; Shannon, Jackilen (Jackie); Thuillier, Philippe; Turker, Mitchell.

C ed. Unknown Publisher, 2010. 21 p. (Advances in Genetics; Vol. 71, No. C).

Research output: Book/ReportBook

Thornburg, Kent ; Shannon, Jackilen (Jackie) ; Thuillier, Philippe ; Turker, Mitchell. / In Utero Life and Epigenetic Predisposition for Disease. C ed. Unknown Publisher, 2010. 21 p. (Advances in Genetics; C).
@book{f030c6ec5ee145c4bb7b2855a2e4982b,
title = "In Utero Life and Epigenetic Predisposition for Disease",
abstract = "Regulatory regions of the human genome can be modified through epigenetic processes during prenatal life to make an individual more likely to suffer chronic diseases when they reach adulthood. The modification of chromatin and DNA contributes to a larger well-documented process known as {"}programming{"} whereby stressors in the womb give rise to adult onset diseases, including cancer. It is now well known that death from ischemic heart disease is related to birth weight; the lower the birth weight, the higher the risk of death from cardiovascular disease as well as type 2 diabetes and osteoporosis. Recent epidemiological data link rapid growth in the womb to metabolic disease and obesity and also to breast and lung cancers. There is increasing evidence that {"}marked{"} regions of DNA can become {"}unmarked{"} under the influence of dietary nutrients. This gives hope for reversing propensities for cancers and other diseases that were acquired in the womb. For several cancers, the size and shape of the placenta are associated with a person's cardiovascular and cancer risks as are maternal body mass index and height. The features of placental growth and nutrient transport properties that lead to adult disease have been little studied. In conclusion, several cancers have their origins in the womb, including lung and breast cancer. More research is needed to determine the epigenetic processes that underlie the programming of these diseases.",
author = "Kent Thornburg and Shannon, {Jackilen (Jackie)} and Philippe Thuillier and Mitchell Turker",
year = "2010",
doi = "10.1016/B978-0-12-380864-6.00003-1",
language = "English (US)",
volume = "71",
series = "Advances in Genetics",
publisher = "Unknown Publisher",
number = "C",
edition = "C",

}

TY - BOOK

T1 - In Utero Life and Epigenetic Predisposition for Disease

AU - Thornburg, Kent

AU - Shannon, Jackilen (Jackie)

AU - Thuillier, Philippe

AU - Turker, Mitchell

PY - 2010

Y1 - 2010

N2 - Regulatory regions of the human genome can be modified through epigenetic processes during prenatal life to make an individual more likely to suffer chronic diseases when they reach adulthood. The modification of chromatin and DNA contributes to a larger well-documented process known as "programming" whereby stressors in the womb give rise to adult onset diseases, including cancer. It is now well known that death from ischemic heart disease is related to birth weight; the lower the birth weight, the higher the risk of death from cardiovascular disease as well as type 2 diabetes and osteoporosis. Recent epidemiological data link rapid growth in the womb to metabolic disease and obesity and also to breast and lung cancers. There is increasing evidence that "marked" regions of DNA can become "unmarked" under the influence of dietary nutrients. This gives hope for reversing propensities for cancers and other diseases that were acquired in the womb. For several cancers, the size and shape of the placenta are associated with a person's cardiovascular and cancer risks as are maternal body mass index and height. The features of placental growth and nutrient transport properties that lead to adult disease have been little studied. In conclusion, several cancers have their origins in the womb, including lung and breast cancer. More research is needed to determine the epigenetic processes that underlie the programming of these diseases.

AB - Regulatory regions of the human genome can be modified through epigenetic processes during prenatal life to make an individual more likely to suffer chronic diseases when they reach adulthood. The modification of chromatin and DNA contributes to a larger well-documented process known as "programming" whereby stressors in the womb give rise to adult onset diseases, including cancer. It is now well known that death from ischemic heart disease is related to birth weight; the lower the birth weight, the higher the risk of death from cardiovascular disease as well as type 2 diabetes and osteoporosis. Recent epidemiological data link rapid growth in the womb to metabolic disease and obesity and also to breast and lung cancers. There is increasing evidence that "marked" regions of DNA can become "unmarked" under the influence of dietary nutrients. This gives hope for reversing propensities for cancers and other diseases that were acquired in the womb. For several cancers, the size and shape of the placenta are associated with a person's cardiovascular and cancer risks as are maternal body mass index and height. The features of placental growth and nutrient transport properties that lead to adult disease have been little studied. In conclusion, several cancers have their origins in the womb, including lung and breast cancer. More research is needed to determine the epigenetic processes that underlie the programming of these diseases.

UR - http://www.scopus.com/inward/record.url?scp=77957333516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957333516&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-380864-6.00003-1

DO - 10.1016/B978-0-12-380864-6.00003-1

M3 - Book

VL - 71

T3 - Advances in Genetics

BT - In Utero Life and Epigenetic Predisposition for Disease

PB - Unknown Publisher

ER -