@article{4fcd7135e3d24358b73bc919d4501501,
title = "In situ analyses of genome instability in breast cancer",
abstract = "Transition through telomere crisis is thought to be a crucial event in the development of most breast carcinomas. Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ.",
author = "Koei Chin and {De Solorzano}, {Carlos Ortiz} and David Knowles and Arthur Jones and William Chou and Rodriguez, {Enrique Garcia} and Kuo, {Wen Lin} and Ljung, {Britt Marie} and Karen Chew and Kenneth Myambol and Monica Miranda and Sheryl Krig and James Garbe and Martha Stampfer and Paul Yaswen and Gray, {Joe W.} and Lockett, {Stephen J.}",
note = "Funding Information: We thank D. Pinkel and D. Albertson for discussions, advice and providing slides for array CGH; C. Thompson for advice concerning the thick-section FISH; and C. Florendo for sectioning the tissue. J.W.G. thanks F. McCormick and colleagues at Leiden University (during a Boerhave Professorship) for discussions of genome evolution in breast cancer. This work was supported by Carl Zeiss, Vysis, the Office of Health and Environmental Research of the US Department of Energy, the US National Institutes of Health, the University of California Breast Cancer Research Program and the Avon Foundation. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government.",
year = "2004",
month = sep,
doi = "10.1038/ng1409",
language = "English (US)",
volume = "36",
pages = "984--988",
journal = "Nature genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",
}