Abstract
The COVID-19 pandemic began in 2019, but it is still active. The development of an effective vaccine reduced the number of deaths; however, a treatment is still needed. Here, we aimed to inhibit viral entry to the host cell by inhibiting spike (S) protein cleavage by several proteases. We developed a computational pipeline to repurpose FDA-approved drugs to inhibit protease activity and thus prevent S protein cleavage. We tested some of our drug candidates and demonstrated a decrease in protease activity. We believe our pipeline will be beneficial in identifying a drug regimen for COVID-19 patients.
Original language | English (US) |
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Article number | 1129 |
Journal | Viruses |
Volume | 14 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2022 |
Keywords
- SARS-CoV-2
- drug repurposing
- in silico screening
- molecular modeling
- proteases
ASJC Scopus subject areas
- Infectious Diseases
- Virology