In silico mapping of complex disease-related traits in mice

A. Grupe; S. Germer; J. Usuka; D. Aud; J. K. Belknap; R. F. Klein; M. K. Ahluwalia; R. Higuchi; G. Peltz

doi:10.1126/science.1058889

In silico mapping of complex disease-related traits in mice

A. Grupe, S. Germer, J. Usuka, D. Aud, J. K. Belknap, R. F. Klein, M. K. Ahluwalia, R. Higuchi, G. Peltz

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

Abstract

Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months clown to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

Original language	English (US)
Pages (from-to)	1915-1918
Number of pages	4
Journal	Science
Volume	292
Issue number	5523
DOIs	https://doi.org/10.1126/science.1058889
State	Published - Jun 8 2001
Externally published	Yes

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title = "In silico mapping of complex disease-related traits in mice",

abstract = "Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months clown to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.",

author = "A. Grupe and S. Germer and J. Usuka and D. Aud and Belknap, {J. K.} and Klein, {R. F.} and Ahluwalia, {M. K.} and R. Higuchi and G. Peltz",

year = "2001",

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AU - Grupe, A.

AU - Germer, S.

AU - Usuka, J.

AU - Aud, D.

AU - Belknap, J. K.

AU - Klein, R. F.

AU - Ahluwalia, M. K.

AU - Higuchi, R.

AU - Peltz, G.

PY - 2001/6/8

Y1 - 2001/6/8

N2 - Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months clown to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

AB - Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months clown to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

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JO - Science

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In silico mapping of complex disease-related traits in mice

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