In silico mapping of complex disease-related traits in mice

A. Grupe, S. Germer, J. Usuka, D. Aud, J. K. Belknap, R. F. Klein, M. K. Ahluwalia, R. Higuchi, G. Peltz

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Abstract

Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months clown to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

Original languageEnglish (US)
Pages (from-to)1915-1918
Number of pages4
JournalScience
Volume292
Issue number5523
DOIs
StatePublished - Jun 8 2001

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Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R., & Peltz, G. (2001). In silico mapping of complex disease-related traits in mice. Science, 292(5523), 1915-1918. https://doi.org/10.1126/science.1058889