In preeclampsia, the placenta grows slowly along its minor axis

Eero Kajantie, Kent Thornburg, Johan G. Eriksson, Clive Osmond, David J P Barker

    Research output: Contribution to journalArticle

    56 Citations (Scopus)

    Abstract

    A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p

    Original languageEnglish (US)
    Pages (from-to)469-473
    Number of pages5
    JournalInternational Journal of Developmental Biology
    Volume54
    Issue number2-3
    DOIs
    StatePublished - 2010

    Fingerprint

    Pre-Eclampsia
    Placenta
    Pregnancy
    Hypertension
    Proteinuria
    Parturition
    Blood Pressure

    Keywords

    • Placental surface
    • Preeclampsia
    • Pregnancy hypertension

    ASJC Scopus subject areas

    • Developmental Biology
    • Embryology
    • Medicine(all)

    Cite this

    In preeclampsia, the placenta grows slowly along its minor axis. / Kajantie, Eero; Thornburg, Kent; Eriksson, Johan G.; Osmond, Clive; Barker, David J P.

    In: International Journal of Developmental Biology, Vol. 54, No. 2-3, 2010, p. 469-473.

    Research output: Contribution to journalArticle

    Kajantie, Eero ; Thornburg, Kent ; Eriksson, Johan G. ; Osmond, Clive ; Barker, David J P. / In preeclampsia, the placenta grows slowly along its minor axis. In: International Journal of Developmental Biology. 2010 ; Vol. 54, No. 2-3. pp. 469-473.
    @article{c93d143921274e3eb81d073b989fa950,
    title = "In preeclampsia, the placenta grows slowly along its minor axis",
    abstract = "A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p",
    keywords = "Placental surface, Preeclampsia, Pregnancy hypertension",
    author = "Eero Kajantie and Kent Thornburg and Eriksson, {Johan G.} and Clive Osmond and Barker, {David J P}",
    year = "2010",
    doi = "10.1387/ijdb.082833ek",
    language = "English (US)",
    volume = "54",
    pages = "469--473",
    journal = "International Journal of Developmental Biology",
    issn = "0214-6282",
    publisher = "University of the Basque Country Press",
    number = "2-3",

    }

    TY - JOUR

    T1 - In preeclampsia, the placenta grows slowly along its minor axis

    AU - Kajantie, Eero

    AU - Thornburg, Kent

    AU - Eriksson, Johan G.

    AU - Osmond, Clive

    AU - Barker, David J P

    PY - 2010

    Y1 - 2010

    N2 - A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p

    AB - A small placental surface area at birth is associated with an increased risk of hypertension in the offspring in later life. Preeclampsia is associated with impaired implantation and with increased blood pressure in the offspring. We hypothesized that preeclampsia would be associated with a small placental surface area. We studied placental size in 6410 deliveries at the Helsinki University Central Hospital during 1934-44. 284 of the pregnancies were complicated by preeclampsia. 1855 were complicated by hypertension without proteinuria. The area of the placental surface was estimated from two diameters that were routinely recorded, a maximal diameter and a lesser one at right angles to it. Compared to normotensive pregnancies, the placentas from pregnancies complicated by preeclampsia had a reduced surface area and the surface was more oval. The thickness, however, was increased. When the two diameters were analyzed together, preeclampsia was not associated with the length of the maximal diameter, but was strongly associated with a short lesser diameter (p

    KW - Placental surface

    KW - Preeclampsia

    KW - Pregnancy hypertension

    UR - http://www.scopus.com/inward/record.url?scp=77950364996&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=77950364996&partnerID=8YFLogxK

    U2 - 10.1387/ijdb.082833ek

    DO - 10.1387/ijdb.082833ek

    M3 - Article

    C2 - 19876819

    AN - SCOPUS:77950364996

    VL - 54

    SP - 469

    EP - 473

    JO - International Journal of Developmental Biology

    JF - International Journal of Developmental Biology

    SN - 0214-6282

    IS - 2-3

    ER -