Improving the efficiency of abdominal aortic aneurysm wall stress computations

Jaime E. Zelaya, Sevan Goenezen, Phong T. Dargon, Amir Azarbal, Sandra Rugonyi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An abdominal aortic aneurysm is a pathological dilation of the abdominal aorta, which carries a high mortality rate if ruptured. The most commonly used surrogate marker of rupture risk is the maximal transverse diameter of the aneurysm. More recent studies suggest that wall stress from models of patient-specific aneurysm geometries extracted, for instance, from computed tomography images may be a more accurate predictor of rupture risk and an important factor in AAA size progression. However, quantification of wall stress is typically computationally intensive and time-consuming, mainly due to the nonlinear mechanical behavior of the abdominal aortic aneurysm walls. These difficulties have limited the potential of computational models in clinical practice. To facilitate computation of wall stresses, we propose to use a linear approach that ensures equilibrium of wall stresses in the aneurysms. This proposed linear model approach is easy to implement and eliminates the burden of nonlinear computations. To assess the accuracy of our proposed approach to compute wall stresses, results from idealized and patient-specific model simulations were compared to those obtained using conventional approaches and to those of a hypothetical, reference abdominal aortic aneurysm model. For the reference model, wall mechanical properties and the initial unloaded and unstressed configuration were assumed to be known, and the resulting wall stresses were used as reference for comparison. Our proposed linear approach accurately approximates wall stresses for varying model geometries and wall material properties. Our findings suggest that the proposed linear approach could be used as an effective, efficient, easy-to-use clinical tool to estimate patient-specific wall stresses.

Original languageEnglish (US)
Article numbere101353
JournalPLoS One
Volume9
Issue number7
DOIs
StatePublished - Jul 9 2014

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aneurysm
Abdominal Aortic Aneurysm
Aneurysm
Rupture
Abdominal Aorta
Dilatation
Linear Models
Biomarkers
Tomography
Mortality
aorta
computed tomography
mechanical properties
Geometry
simulation models
linear models
Materials properties
Mechanical properties

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Improving the efficiency of abdominal aortic aneurysm wall stress computations. / Zelaya, Jaime E.; Goenezen, Sevan; Dargon, Phong T.; Azarbal, Amir; Rugonyi, Sandra.

In: PLoS One, Vol. 9, No. 7, e101353, 09.07.2014.

Research output: Contribution to journalArticle

Zelaya, Jaime E. ; Goenezen, Sevan ; Dargon, Phong T. ; Azarbal, Amir ; Rugonyi, Sandra. / Improving the efficiency of abdominal aortic aneurysm wall stress computations. In: PLoS One. 2014 ; Vol. 9, No. 7.
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