Improvement in sleep and itch and enhanced quality of life in adult patients with moderate-to-severe atopic dermatitis: results from a phase 3 trial of baricitinib therapy

Peter A. Lio, Eric L. Simpson, George Han, Jennifer Soung, Susan Ball, Luna Sun, Marta Casillas, Amy M. DeLozier, Yuxin Ding, Lawrence F. Eichenfield

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Baricitinib previously demonstrated improvements in itch and sleep disturbance versus placebo in adults with moderate-to-severe atopic dermatitis (AD). Objectives: Examine if itch and sleep improvements are associated with better quality of life (QoL) and productivity in patients with AD. Methods: Data were drawn from BREEZE-AD5 (NCT03435081). Itch and sleep improvement at Week 16 were defined using ≥4-point improvements in the Itch Numeric Rating Scale and ≥1.5 decreases in the number of nighttime awakenings since baseline, respectively. Patients with and without improvements were compared on Dermatology Life Quality Index (DLQI) and Work Productivity and Activity Impairment-AD scores. Changes from baseline were analyzed using ANCOVA with last observation carried forward. Proportions were analyzed using logistic regression with non-responder imputation. Results: Greater proportions of patients with versus without itch improvement indicated no impact of AD on QoL (37.7 vs. 1.8%). Patients with itch improvement had greater decreases in work time impaired (−29.3 vs. −5.6%). More patients with versus without sleep improvement reported no effect of AD on QoL (25.5 vs. 1.1%); patients with better sleep experienced larger reductions in work time spent impaired (−33.3 vs. −6.1%). Conclusions: Patients with AD who experienced itch and sleep improvement had significantly better QoL and productivity.

Original languageEnglish (US)
Pages (from-to)2057-2062
Number of pages6
JournalJournal of Dermatological Treatment
Volume33
Issue number4
DOIs
StatePublished - 2022

Keywords

  • Atopic dermatitis
  • baricitinib
  • productivity
  • quality of life

ASJC Scopus subject areas

  • Dermatology

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