Improved survival for adenocarcinoma of the ampulla of Vater: Fifty-five consecutive resections

John P. Duffy, Oscar J. Hines, Jerome H. Liu, Clifford Y. Ko, Galen Cortina, William H. Isacoff, Henry Nguyen, Michael Leonardi, Ronald K. Tompkins, Howard A. Reber, Clifford Deveney, Karen Deveney, Theodore X. O'Connell

Research output: Contribution to journalArticle

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Abstract

Hypothesis: After resection of an adenocarcinoma of the ampulla of Vater, certain clinical and pathologic characteristics influence long-term survival. Design: Retrospective case series. Setting: Major academic medical and pancreatic surgical center. Patients: Fifty-five consecutive patients who underwent Whipple resection for ampullary adenocarcinoma from 1988 through 2001. Interventions: Pylorus-preserving Whipple resection in 32 patients and standard Whipple resection in 23 patients. Main Outcome Measures: Postoperative survival. A multivariate Cox proportional hazards model was used to determine the effects of various factors on long-term survival after resection. Results: There were no operative deaths, and all patients left the hospital. After a mean follow-up of 46.9 months, the overall 5-year Kaplan-Meier survival estimate was 67.7%. The median survival of the entire group has not yet been reached. Five-year postoperative survival estimates for node-negative (n=32) and node-positive patients (n=23) were 76.5% and 53.4%, respectively (P=.26). Patients whose tumors demonstrated perineural invasion (n=12) had a 5-year survival estimate of 29.2% vs 78.8% for those whose did not (P

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalArchives of Surgery
Volume138
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

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Ampulla of Vater
Adenocarcinoma
Survival
Pylorus
Kaplan-Meier Estimate
Proportional Hazards Models
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Surgery

Cite this

Duffy, J. P., Hines, O. J., Liu, J. H., Ko, C. Y., Cortina, G., Isacoff, W. H., ... O'Connell, T. X. (2003). Improved survival for adenocarcinoma of the ampulla of Vater: Fifty-five consecutive resections. Archives of Surgery, 138(9), 941-950. https://doi.org/10.1001/archsurg.138.9.941

Improved survival for adenocarcinoma of the ampulla of Vater : Fifty-five consecutive resections. / Duffy, John P.; Hines, Oscar J.; Liu, Jerome H.; Ko, Clifford Y.; Cortina, Galen; Isacoff, William H.; Nguyen, Henry; Leonardi, Michael; Tompkins, Ronald K.; Reber, Howard A.; Deveney, Clifford; Deveney, Karen; O'Connell, Theodore X.

In: Archives of Surgery, Vol. 138, No. 9, 01.09.2003, p. 941-950.

Research output: Contribution to journalArticle

Duffy, JP, Hines, OJ, Liu, JH, Ko, CY, Cortina, G, Isacoff, WH, Nguyen, H, Leonardi, M, Tompkins, RK, Reber, HA, Deveney, C, Deveney, K & O'Connell, TX 2003, 'Improved survival for adenocarcinoma of the ampulla of Vater: Fifty-five consecutive resections', Archives of Surgery, vol. 138, no. 9, pp. 941-950. https://doi.org/10.1001/archsurg.138.9.941
Duffy, John P. ; Hines, Oscar J. ; Liu, Jerome H. ; Ko, Clifford Y. ; Cortina, Galen ; Isacoff, William H. ; Nguyen, Henry ; Leonardi, Michael ; Tompkins, Ronald K. ; Reber, Howard A. ; Deveney, Clifford ; Deveney, Karen ; O'Connell, Theodore X. / Improved survival for adenocarcinoma of the ampulla of Vater : Fifty-five consecutive resections. In: Archives of Surgery. 2003 ; Vol. 138, No. 9. pp. 941-950.
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