Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine

Edward O. McFalls, George Pantely, Cheryl G. Anselone, David J. Bristow

    Research output: Contribution to journalArticle

    Abstract

    Study objective - The aim was to test the hypothesis that the release of vascular tone with adenosine during constant flow ischaemia alters both transmural function and regional metabolism in a detrimental way. Design - In one group of anaesthetised swine, the effects of graded reductions of flow on segmental left ventricular function, myocardial oxygen consumption (MVO2), and lactate production in the distribution of the left anterior descending coronary artery (LAD) were determined. In a second group, a model of constant flow ischaemia was induced to test how altering vascular tone with adenosine changed the relationship of flow, function, and metabolism. Experimental material - The experiments were performed in 20 open chest, anaesthetised swine. Protocol A consisted of 11 animals and protocol B of nine animals. Measurements and main results - In protocol A, during graded ischaemia, reductions in flow, % systolic wall thickening (WTh), normalised MVO2 and % lactate extraction (%LE) correlated well with reductions in coronary perfusion pressure when fitted with 3rd order polynominal curves (r = 0.78, 0.87, 0.85 and 0.81 respectively; p-1·g-1, and % LE was +14(9)%. With inflation of a hydraulic occluder on the LAD, perfusion pressure was lowered to 38(5) mm Hg and transmural flow dropped to 0.76(0.31) ml·min-1·g-1 (intact vasomotion). During an infusion of intracoronary adenosine with flow held constant (absent vasomotion), %WTh was further reduced from 27(9) to 13(10) (p2 with and without vasomotion did not differ significantly at 3.14(0.75) and 3.18(0.86) ml·min-1·g-1 respectively. Conclusion - In swine coronary circulation, reductions in regional function, MVO2 and lactate production correlate well with reductions in flow and perfusion pressure during ischaemia with vasomotor tone intact. The effect of adenosine on vascular tone during constant flow ischaemia caused dramatic reductions in function and lactate extraction without altering MVO2. This emphasises the important role of vascular tone in protecting both transmural function and regional metabolism during moderate ischaemia.

    Original languageEnglish (US)
    Pages (from-to)813-820
    Number of pages8
    JournalCardiovascular Research
    Volume24
    Issue number10
    StatePublished - 1990

    Fingerprint

    Myocardial Function
    Ischemia
    Metabolism
    Swine
    Adenosine
    Blood Vessels
    Lactic Acid
    Perfusion
    Pressure
    Animals
    Coronary Circulation
    Economic Inflation
    Left Ventricular Function
    Oxygen Consumption
    Coronary Vessels
    Thorax
    Coronary Artery
    Hydraulics
    Inflation
    Correlate

    Keywords

    • Adenosine
    • Constant flow ischaemia
    • Vasomotion

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Statistics, Probability and Uncertainty
    • Applied Mathematics
    • Physiology (medical)
    • Physiology

    Cite this

    McFalls, E. O., Pantely, G., Anselone, C. G., & Bristow, D. J. (1990). Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine. Cardiovascular Research, 24(10), 813-820.

    Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine. / McFalls, Edward O.; Pantely, George; Anselone, Cheryl G.; Bristow, David J.

    In: Cardiovascular Research, Vol. 24, No. 10, 1990, p. 813-820.

    Research output: Contribution to journalArticle

    McFalls, EO, Pantely, G, Anselone, CG & Bristow, DJ 1990, 'Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine', Cardiovascular Research, vol. 24, no. 10, pp. 813-820.
    McFalls, Edward O. ; Pantely, George ; Anselone, Cheryl G. ; Bristow, David J. / Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine. In: Cardiovascular Research. 1990 ; Vol. 24, No. 10. pp. 813-820.
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    N2 - Study objective - The aim was to test the hypothesis that the release of vascular tone with adenosine during constant flow ischaemia alters both transmural function and regional metabolism in a detrimental way. Design - In one group of anaesthetised swine, the effects of graded reductions of flow on segmental left ventricular function, myocardial oxygen consumption (MVO2), and lactate production in the distribution of the left anterior descending coronary artery (LAD) were determined. In a second group, a model of constant flow ischaemia was induced to test how altering vascular tone with adenosine changed the relationship of flow, function, and metabolism. Experimental material - The experiments were performed in 20 open chest, anaesthetised swine. Protocol A consisted of 11 animals and protocol B of nine animals. Measurements and main results - In protocol A, during graded ischaemia, reductions in flow, % systolic wall thickening (WTh), normalised MVO2 and % lactate extraction (%LE) correlated well with reductions in coronary perfusion pressure when fitted with 3rd order polynominal curves (r = 0.78, 0.87, 0.85 and 0.81 respectively; p-1·g-1, and % LE was +14(9)%. With inflation of a hydraulic occluder on the LAD, perfusion pressure was lowered to 38(5) mm Hg and transmural flow dropped to 0.76(0.31) ml·min-1·g-1 (intact vasomotion). During an infusion of intracoronary adenosine with flow held constant (absent vasomotion), %WTh was further reduced from 27(9) to 13(10) (p2 with and without vasomotion did not differ significantly at 3.14(0.75) and 3.18(0.86) ml·min-1·g-1 respectively. Conclusion - In swine coronary circulation, reductions in regional function, MVO2 and lactate production correlate well with reductions in flow and perfusion pressure during ischaemia with vasomotor tone intact. The effect of adenosine on vascular tone during constant flow ischaemia caused dramatic reductions in function and lactate extraction without altering MVO2. This emphasises the important role of vascular tone in protecting both transmural function and regional metabolism during moderate ischaemia.

    AB - Study objective - The aim was to test the hypothesis that the release of vascular tone with adenosine during constant flow ischaemia alters both transmural function and regional metabolism in a detrimental way. Design - In one group of anaesthetised swine, the effects of graded reductions of flow on segmental left ventricular function, myocardial oxygen consumption (MVO2), and lactate production in the distribution of the left anterior descending coronary artery (LAD) were determined. In a second group, a model of constant flow ischaemia was induced to test how altering vascular tone with adenosine changed the relationship of flow, function, and metabolism. Experimental material - The experiments were performed in 20 open chest, anaesthetised swine. Protocol A consisted of 11 animals and protocol B of nine animals. Measurements and main results - In protocol A, during graded ischaemia, reductions in flow, % systolic wall thickening (WTh), normalised MVO2 and % lactate extraction (%LE) correlated well with reductions in coronary perfusion pressure when fitted with 3rd order polynominal curves (r = 0.78, 0.87, 0.85 and 0.81 respectively; p-1·g-1, and % LE was +14(9)%. With inflation of a hydraulic occluder on the LAD, perfusion pressure was lowered to 38(5) mm Hg and transmural flow dropped to 0.76(0.31) ml·min-1·g-1 (intact vasomotion). During an infusion of intracoronary adenosine with flow held constant (absent vasomotion), %WTh was further reduced from 27(9) to 13(10) (p2 with and without vasomotion did not differ significantly at 3.14(0.75) and 3.18(0.86) ml·min-1·g-1 respectively. Conclusion - In swine coronary circulation, reductions in regional function, MVO2 and lactate production correlate well with reductions in flow and perfusion pressure during ischaemia with vasomotor tone intact. The effect of adenosine on vascular tone during constant flow ischaemia caused dramatic reductions in function and lactate extraction without altering MVO2. This emphasises the important role of vascular tone in protecting both transmural function and regional metabolism during moderate ischaemia.

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