Implicit memory for complex sounds in higher auditory cortex of the ferret

Kai Lu, Wanyi Liu, Peng Zan, Stephen David, Jonathan B. Fritz, Shihab A. Shamma

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Responses of auditory cortical neurons encode sound features of incoming acoustic stimuli and also are shaped by stimulus context and history. Previous studies of mammalian auditory cortex have reported a variable time course for such contextual effects ranging from milliseconds to minutes. However, in secondary auditory forebrain areas of songbirds, long-term stimulus-specific neuronal habituation to acoustic stimuli can persist for much longer periods of time, ranging from hours to days. Such long-term habituation in the songbird is a form of long-term auditory memory that requires gene expression. Although such long-term habituation has been demonstrated in avian auditory forebrain, this phenomenon has not previously been described in the mammalian auditory system. Utilizing a similar version of the avian habituation paradigm, we explored whether such long-term effects of stimulus history also occur in auditory cortex of a mammalian auditory generalist, the ferret. Following repetitive presentation of novel complex sounds, we observed significant response habituation in secondary auditory cortex, but not in primary auditory cortex. This long-term habituation appeared to be independent for each novel stimulus and often lasted for at least 20 min. These effects could not be explained by simple neuronal fatigue in the auditory pathway, because time-reversed sounds induced undiminished responses similar to those elicited by completely novel sounds. A parallel set of pupillometric response measurements in the ferret revealed long-term habituation effects similar to observed long-term neural habituation, supporting the hypothesis that habituation to passively presented stimuli is correlated with implicit learning and long-term recognition of familiar sounds.

Original languageEnglish (US)
Pages (from-to)9955-9966
Number of pages12
JournalJournal of Neuroscience
Volume38
Issue number46
DOIs
StatePublished - Nov 14 2018

Fingerprint

Ferrets
Auditory Cortex
Songbirds
Prosencephalon
Acoustics
History
Auditory Pathways
Long-Term Memory
Fatigue
Learning
Gene Expression
Neurons

Keywords

  • Auditory cortex
  • Habituation
  • Long-term memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Implicit memory for complex sounds in higher auditory cortex of the ferret. / Lu, Kai; Liu, Wanyi; Zan, Peng; David, Stephen; Fritz, Jonathan B.; Shamma, Shihab A.

In: Journal of Neuroscience, Vol. 38, No. 46, 14.11.2018, p. 9955-9966.

Research output: Contribution to journalArticle

Lu, Kai ; Liu, Wanyi ; Zan, Peng ; David, Stephen ; Fritz, Jonathan B. ; Shamma, Shihab A. / Implicit memory for complex sounds in higher auditory cortex of the ferret. In: Journal of Neuroscience. 2018 ; Vol. 38, No. 46. pp. 9955-9966.
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