Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1

Navid Madani, Robert Millette, Emily J. Platt, Mariana Marin, Susan L. Kozak, Donald B. Bloch, David Kabat

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The viral infectivity factor (Vif) of human immunodeficiency virus type 1 (HIV-1) neutralizes an unidentified antiviral pathway that occurs only in nonpermissive (NP) cells. Using a yeast two-hybrid screen of a human lymphocyte cDNA library, we identified several potential Vif partners. One, the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P ≤ 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif. Our results implicate Spl40 in a response to HIV-1 that may be related to or coordinated with the pathway that inactivates HIV-1 lacking vif.

Original languageEnglish (US)
Pages (from-to)11133-11138
Number of pages6
JournalJournal of virology
Volume76
Issue number21
DOIs
StatePublished - Nov 1 2002

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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