Context: There is a growing interest in and need for continuing education in medical informatics delivered by distance learning. Objectives: Implement and evaluate a distance learning introductory course in medical informatics. Methods: A Web-based version of our on-campus 'Introduction to Medical Informatics' course was implemented using streaming audio lectures, threaded discussion boards, and several other teaching modalities. Evaluation was performed using an adaptation of our on-campus course evaluation instrument. Results: The course was implemented with no major technological or pedagogical problems. Student satisfaction with teaching modalities and other course modalities was high. Conclusions: The learning technologies used in this course were implemented successfully and a Graduate Certificate Program is planned to further meet educational needs in medical informatics.