Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies

Biplab Sarkar, Zain Siddiqui, Ka Kyung Kim, Peter K. Nguyen, Xavier Reyes, Trevor J. McGill, Vivek A. Kumar

Research output: Contribution to journalReview article

Abstract

The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration. Currently, these diseases are mainly treated with anti-VEGF drugs (VEGF = vascular endothelial growth factor), generally on a monthly dosage scheme. We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. [Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)1191-1202
Number of pages12
JournalDrug Delivery and Translational Research
Volume10
Issue number5
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • Age-related macular degeneration
  • Anti-angiogenic materials
  • Diabetic retinopathy
  • Hydrogel
  • Pathological neovascularization
  • Peptide nanofibers
  • Self-assembly

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Sarkar, B., Siddiqui, Z., Kim, K. K., Nguyen, P. K., Reyes, X., McGill, T. J., & Kumar, V. A. (Accepted/In press). Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies. Drug Delivery and Translational Research, 10(5), 1191-1202. https://doi.org/10.1007/s13346-020-00753-0