Impairments of the protein C system and fibrinolysis in infection- associated stroke

Richard F. Macko, Sebastian F. Ameriso, Andras Gruber, John H. Griffin, Jose A. Fernandez, Robert Barndt, Francisco P. Quismorio, John M. Weiner, Mark Fisher

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background and Purpose: Infection/inflammation appears to be an important predisposing risk factor for brain infarction, but little is known regarding underlying molecular mechanisms. We examined the hypothesis that patients with brain infarction preceded by infection/inflammation within 1 week could be identified by a distinctive procoagulant laboratory profile characterized by abnormalities in the protein C system and endogenous fibrinolysis. Methods: We performed a case control study examining the relationship between preceding systemic infectious/inflammatory syndromes and selected immunohematologic variables in 36 patients with acute brain infarction and 81 control subjects (community control subjects [n=47] and hospitalized nonstroke neurological patient controls [n=34]). Results: The stroke group had a lower incan level of the circulating antithrombotic enzyme activated protein C (APC) (4.33±0.34% [log-transformed percentage of control value, mean±SD]) than community control subjects (4.51 ± 0.27%, P

Original languageEnglish (US)
Pages (from-to)2005-2011
Number of pages7
JournalStroke
Volume27
Issue number11
StatePublished - Nov 1996
Externally publishedYes

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Brain Infarction
Fibrinolysis
Protein C
Stroke
Infection
Inflammation
Causality
Case-Control Studies
Enzymes

Keywords

  • blood coagulation
  • blood proteins
  • cerebral infarction
  • fibrinolysis
  • infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Macko, R. F., Ameriso, S. F., Gruber, A., Griffin, J. H., Fernandez, J. A., Barndt, R., ... Fisher, M. (1996). Impairments of the protein C system and fibrinolysis in infection- associated stroke. Stroke, 27(11), 2005-2011.

Impairments of the protein C system and fibrinolysis in infection- associated stroke. / Macko, Richard F.; Ameriso, Sebastian F.; Gruber, Andras; Griffin, John H.; Fernandez, Jose A.; Barndt, Robert; Quismorio, Francisco P.; Weiner, John M.; Fisher, Mark.

In: Stroke, Vol. 27, No. 11, 11.1996, p. 2005-2011.

Research output: Contribution to journalArticle

Macko, RF, Ameriso, SF, Gruber, A, Griffin, JH, Fernandez, JA, Barndt, R, Quismorio, FP, Weiner, JM & Fisher, M 1996, 'Impairments of the protein C system and fibrinolysis in infection- associated stroke', Stroke, vol. 27, no. 11, pp. 2005-2011.
Macko RF, Ameriso SF, Gruber A, Griffin JH, Fernandez JA, Barndt R et al. Impairments of the protein C system and fibrinolysis in infection- associated stroke. Stroke. 1996 Nov;27(11):2005-2011.
Macko, Richard F. ; Ameriso, Sebastian F. ; Gruber, Andras ; Griffin, John H. ; Fernandez, Jose A. ; Barndt, Robert ; Quismorio, Francisco P. ; Weiner, John M. ; Fisher, Mark. / Impairments of the protein C system and fibrinolysis in infection- associated stroke. In: Stroke. 1996 ; Vol. 27, No. 11. pp. 2005-2011.
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