Impairments in spatial memory retention of GFAP-apoE4 female mice

Peter van Meer; Summer Acevedo; Jacob Raber

doi:10.1016/j.bbr.2006.10.024

Impairments in spatial memory retention of GFAP-apoE4 female mice

Peter van Meer, Summer Acevedo, Jacob Raber

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

Original language	English (US)
Pages (from-to)	372-375
Number of pages	4
Journal	Behavioural Brain Research
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2006.10.024
State	Published - Jan 25 2007

Keywords

Apolipoprotein E
Passive avoidance
Rotorod
Transgenic mice
Water maze

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2006.10.024

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title = "Impairments in spatial memory retention of GFAP-apoE4 female mice",

abstract = "The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.",

keywords = "Apolipoprotein E, Passive avoidance, Rotorod, Transgenic mice, Water maze",

author = "{van Meer}, Peter and Summer Acevedo and Jacob Raber",

note = "Funding Information: We thank Laura Villasana and Wolf Gremel for assistance with the behavioral testing. We thank Cara Poage for assistance with breeding and genotyping of the mice. We thank Theodore S. Benice for assistance with the statistical analysis of the data. This work was supported by NIH Grants R01 AG20904 and EMF AG-NS-0201-02. ",

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AU - van Meer, Peter

AU - Acevedo, Summer

AU - Raber, Jacob

N1 - Funding Information: We thank Laura Villasana and Wolf Gremel for assistance with the behavioral testing. We thank Cara Poage for assistance with breeding and genotyping of the mice. We thank Theodore S. Benice for assistance with the statistical analysis of the data. This work was supported by NIH Grants R01 AG20904 and EMF AG-NS-0201-02.

PY - 2007/1/25

Y1 - 2007/1/25

N2 - The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

AB - The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

KW - Apolipoprotein E

KW - Passive avoidance

KW - Rotorod

KW - Transgenic mice

KW - Water maze

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Impairments in spatial memory retention of GFAP-apoE4 female mice

Abstract

Keywords

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