Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated with Mortality in Eisenmenger Syndrome

A Clinical and Cardiovascular Magnetic Resonance Study

Annette S. Jensen, Craig Broberg, Riikka Rydman, Gerhard Paul Diller, Wei Li, Konstantinos Dimopoulos, Stephen J. Wort, Dudley J. Pennell, Michael A. Gatzoulis, Sonya V. Babu-Narayan

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Background - Patients with Eisenmenger syndrome (ES) have better survival, despite similar pulmonary vascular pathology, compared with other patients with pulmonary arterial hypertension. Cardiovascular magnetic resonance (CMR) is useful for risk stratification in idiopathic pulmonary arterial hypertension, whereas it has not been evaluated in ES. We studied CMR together with other noninvasive measurements in ES to evaluate its potential role as a noninvasive risk stratification test. Methods and Results - Between 2003 and 2005, 48 patients with ES, all with a post-tricuspid shunt, were enrolled in a prospective, longitudinal, single-center study. All patients underwent a standardized baseline assessment with CMR, blood test, echocardiography, and 6-minute walk test and were followed up for mortality until the end of December 2013. Twelve patients (25%) died during follow-up, mostly from heart failure (50%). Impaired ventricular function (right or left ventricular ejection fraction) was associated with increased risk of mortality (lowest quartile: right ventricular ejection fraction,

    Original languageEnglish (US)
    Article numbere003596
    JournalCirculation: Cardiovascular Imaging
    Volume8
    Issue number12
    DOIs
    StatePublished - Dec 1 2015

    Fingerprint

    Eisenmenger Complex
    Magnetic Resonance Spectroscopy
    Oxygen
    Mortality
    Stroke Volume
    Right Ventricular Function
    Hematologic Tests
    Left Ventricular Function
    Pulmonary Hypertension
    Blood Vessels
    Echocardiography
    Heart Failure
    Pathology
    Lung
    Survival

    Keywords

    • Eisenmenger syndrome
    • follow-up studies
    • magnetic resonance imaging
    • mortality

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Radiology Nuclear Medicine and imaging

    Cite this

    Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated with Mortality in Eisenmenger Syndrome : A Clinical and Cardiovascular Magnetic Resonance Study. / Jensen, Annette S.; Broberg, Craig; Rydman, Riikka; Diller, Gerhard Paul; Li, Wei; Dimopoulos, Konstantinos; Wort, Stephen J.; Pennell, Dudley J.; Gatzoulis, Michael A.; Babu-Narayan, Sonya V.

    In: Circulation: Cardiovascular Imaging, Vol. 8, No. 12, e003596, 01.12.2015.

    Research output: Contribution to journalArticle

    Jensen, Annette S. ; Broberg, Craig ; Rydman, Riikka ; Diller, Gerhard Paul ; Li, Wei ; Dimopoulos, Konstantinos ; Wort, Stephen J. ; Pennell, Dudley J. ; Gatzoulis, Michael A. ; Babu-Narayan, Sonya V. / Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated with Mortality in Eisenmenger Syndrome : A Clinical and Cardiovascular Magnetic Resonance Study. In: Circulation: Cardiovascular Imaging. 2015 ; Vol. 8, No. 12.
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    abstract = "Background - Patients with Eisenmenger syndrome (ES) have better survival, despite similar pulmonary vascular pathology, compared with other patients with pulmonary arterial hypertension. Cardiovascular magnetic resonance (CMR) is useful for risk stratification in idiopathic pulmonary arterial hypertension, whereas it has not been evaluated in ES. We studied CMR together with other noninvasive measurements in ES to evaluate its potential role as a noninvasive risk stratification test. Methods and Results - Between 2003 and 2005, 48 patients with ES, all with a post-tricuspid shunt, were enrolled in a prospective, longitudinal, single-center study. All patients underwent a standardized baseline assessment with CMR, blood test, echocardiography, and 6-minute walk test and were followed up for mortality until the end of December 2013. Twelve patients (25{\%}) died during follow-up, mostly from heart failure (50{\%}). Impaired ventricular function (right or left ventricular ejection fraction) was associated with increased risk of mortality (lowest quartile: right ventricular ejection fraction,",
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