Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: A randomized controlled trial

K. M. Winters-Stone, J. Dobek, L. M. Nail, J. A. Bennett, M. C. Leo, B. Torgrimson-Ojerio, S. W. Luoh, A. Schwartz

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p < 0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p < 0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p < 0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

Original languageEnglish (US)
Pages (from-to)1637-1646
Number of pages10
JournalOsteoporosis International
Volume24
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • Chemotherapy
  • Neoplasm
  • Obesity
  • Osteoporosis
  • Physical activity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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