Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: A randomized controlled trial

Kerri Winters-Stone, J. Dobek, Lillian Nail, Jill Bennett, M. C. Leo, B. Torgrimson-Ojerio, Shiuh-Wen Luoh, A. Schwartz

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p <0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p <0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p <0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

Original languageEnglish (US)
Pages (from-to)1637-1646
Number of pages10
JournalOsteoporosis International
Volume24
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Resistance Training
Body Composition
Osteoporosis
Survivors
Bone Density
Randomized Controlled Trials
Breast Neoplasms
Bone and Bones
Pelvic Bones
Health
Spine
Premature Menopause
Bone Remodeling
Menopause
Adipose Tissue
Fats
Exercise
Second Primary Neoplasms
Femur Neck
Osteocalcin

Keywords

  • Chemotherapy
  • Neoplasm
  • Obesity
  • Osteoporosis
  • Physical activity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors : A randomized controlled trial. / Winters-Stone, Kerri; Dobek, J.; Nail, Lillian; Bennett, Jill; Leo, M. C.; Torgrimson-Ojerio, B.; Luoh, Shiuh-Wen; Schwartz, A.

In: Osteoporosis International, Vol. 24, No. 5, 05.2013, p. 1637-1646.

Research output: Contribution to journalArticle

Winters-Stone, Kerri ; Dobek, J. ; Nail, Lillian ; Bennett, Jill ; Leo, M. C. ; Torgrimson-Ojerio, B. ; Luoh, Shiuh-Wen ; Schwartz, A. / Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors : A randomized controlled trial. In: Osteoporosis International. 2013 ; Vol. 24, No. 5. pp. 1637-1646.
@article{966f274430cb4619aa8743c8a42d772b,
title = "Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: A randomized controlled trial",
abstract = "Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat ({\%}BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p <0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in {\%}BF (POWIR, 0.01 {\%} vs. FLEX, 1.3 {\%}; p <0.04). Women with attendance to POWIR at ≥64 {\%} had better improvements in {\%}BF than women attending less often (p <0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.",
keywords = "Chemotherapy, Neoplasm, Obesity, Osteoporosis, Physical activity",
author = "Kerri Winters-Stone and J. Dobek and Lillian Nail and Jill Bennett and Leo, {M. C.} and B. Torgrimson-Ojerio and Shiuh-Wen Luoh and A. Schwartz",
year = "2013",
month = "5",
doi = "10.1007/s00198-012-2143-2",
language = "English (US)",
volume = "24",
pages = "1637--1646",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "5",

}

TY - JOUR

T1 - Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors

T2 - A randomized controlled trial

AU - Winters-Stone, Kerri

AU - Dobek, J.

AU - Nail, Lillian

AU - Bennett, Jill

AU - Leo, M. C.

AU - Torgrimson-Ojerio, B.

AU - Luoh, Shiuh-Wen

AU - Schwartz, A.

PY - 2013/5

Y1 - 2013/5

N2 - Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p <0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p <0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p <0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

AB - Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p <0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p <0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p <0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.

KW - Chemotherapy

KW - Neoplasm

KW - Obesity

KW - Osteoporosis

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=84881511614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881511614&partnerID=8YFLogxK

U2 - 10.1007/s00198-012-2143-2

DO - 10.1007/s00198-012-2143-2

M3 - Article

C2 - 22996743

AN - SCOPUS:84881511614

VL - 24

SP - 1637

EP - 1646

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 5

ER -