Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes

A Summary of Workshop Discussions

Deanna M. Arble, Joseph Bass, Cecilia Diniz Behn, Matthew Butler, Etienne Challet, Charles Czeisler, Christopher M. Depner, Joel Elmquist, Paul Franken, Michael A. Grandner, Erin C. Hanlon, Alex C. Keene, Michael J. Joyner, Ilia Karatsoreos, Philip A. Kern, Samuel Klein, Christopher J. Morris, Allan I. Pack, Satchidananda Panda, Louis J. Ptacek & 8 others Naresh M. Punjabi, Paolo Sassone-Corsi, Frank A. Scheer, Richa Saxena, Elizabeth R. Seaquest, Matthew S. Thimgan, Eve Van Cauter, Kenneth P. Wright

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.

Original languageEnglish (US)
Pages (from-to)1849-1860
Number of pages12
JournalSleep
Volume38
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Sleep
Education
Research Personnel
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Research
Needs Assessment
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Circadian Rhythm
Cohort Studies
Public Health
Obesity
Insulin
Glucose
Population
Therapeutics

Keywords

  • circadian disruption
  • circadian rhythm
  • diabetes
  • insulin resistance
  • metabolism
  • obesity
  • short sleep
  • sleep apnea
  • sleep disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Arble, D. M., Bass, J., Behn, C. D., Butler, M., Challet, E., Czeisler, C., ... Wright, K. P. (2015). Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep, 38(12), 1849-1860. https://doi.org/10.5665/sleep.5226

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes : A Summary of Workshop Discussions. / Arble, Deanna M.; Bass, Joseph; Behn, Cecilia Diniz; Butler, Matthew; Challet, Etienne; Czeisler, Charles; Depner, Christopher M.; Elmquist, Joel; Franken, Paul; Grandner, Michael A.; Hanlon, Erin C.; Keene, Alex C.; Joyner, Michael J.; Karatsoreos, Ilia; Kern, Philip A.; Klein, Samuel; Morris, Christopher J.; Pack, Allan I.; Panda, Satchidananda; Ptacek, Louis J.; Punjabi, Naresh M.; Sassone-Corsi, Paolo; Scheer, Frank A.; Saxena, Richa; Seaquest, Elizabeth R.; Thimgan, Matthew S.; Van Cauter, Eve; Wright, Kenneth P.

In: Sleep, Vol. 38, No. 12, 01.12.2015, p. 1849-1860.

Research output: Contribution to journalArticle

Arble, DM, Bass, J, Behn, CD, Butler, M, Challet, E, Czeisler, C, Depner, CM, Elmquist, J, Franken, P, Grandner, MA, Hanlon, EC, Keene, AC, Joyner, MJ, Karatsoreos, I, Kern, PA, Klein, S, Morris, CJ, Pack, AI, Panda, S, Ptacek, LJ, Punjabi, NM, Sassone-Corsi, P, Scheer, FA, Saxena, R, Seaquest, ER, Thimgan, MS, Van Cauter, E & Wright, KP 2015, 'Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions', Sleep, vol. 38, no. 12, pp. 1849-1860. https://doi.org/10.5665/sleep.5226
Arble, Deanna M. ; Bass, Joseph ; Behn, Cecilia Diniz ; Butler, Matthew ; Challet, Etienne ; Czeisler, Charles ; Depner, Christopher M. ; Elmquist, Joel ; Franken, Paul ; Grandner, Michael A. ; Hanlon, Erin C. ; Keene, Alex C. ; Joyner, Michael J. ; Karatsoreos, Ilia ; Kern, Philip A. ; Klein, Samuel ; Morris, Christopher J. ; Pack, Allan I. ; Panda, Satchidananda ; Ptacek, Louis J. ; Punjabi, Naresh M. ; Sassone-Corsi, Paolo ; Scheer, Frank A. ; Saxena, Richa ; Seaquest, Elizabeth R. ; Thimgan, Matthew S. ; Van Cauter, Eve ; Wright, Kenneth P. / Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes : A Summary of Workshop Discussions. In: Sleep. 2015 ; Vol. 38, No. 12. pp. 1849-1860.
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