Impact of recent seizures on cerebral blood flow in patients with sturge-weber syndrome: Study of 2 cases

Kader K. Oguz, Senem Senturk, Arzu Ozturk, Banu Anlar, Meral Topcu, Aysenur Cila

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Patients with refractory seizures, including those with Sturge-Weber syndrome, undergo functional studies in preparation for surgery. Perfusion studies in Sturge-Weber syndrome by single photon emission computed tomography and positron emission tomography generally demonstrate hypoperfusion in the diseased tissue. We report perfusion-weighted magnetic resonance imaging results in 2 cases of Sturge-Weber syndrome with recent seizures. The affected cerebral tissue showed increased relative cerebral blood flow and volume with prolonged mean transit time and time to peak. Elevated relative cerebral blood flow could be attributed to seizures, whereas increased relative cerebral blood volume might have resulted from vasodilation due to seizure activity or chronic ischemia. These findings point to the variable results of functional studies in Sturge-Weber syndrome that might lead to miscalculations of the lesion area before surgery.

Original languageEnglish (US)
Pages (from-to)617-620
Number of pages4
JournalJournal of child neurology
Volume22
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • Magnetic resonance imaging
  • Perfusion-weighted imaging
  • Seizure
  • Sturge-Weber syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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