Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: Single and double dosing

Alison B. Edelman, Ganesh Cherala, Steven W. Blue, David W. Erikson, Jeffrey T. Jensen

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objective To determine if differences exist in the pharmacokinetics (PK) of levonorgestrel-based emergency contraception (LNG-EC) in obese and normal body mass index (BMI) users and test whether doubling the dose of LNG-EC in obese women increases total and free (active) LNG serum concentrations. Study design Healthy, reproductive-age women with obese and normal BMIs received 1.5 mg LNG orally (ECx1) and then in a subsequent menstrual cycle, the obese group also received 3 mg LNG (ECx2). Dosing occurred during the follicular phase. Total and free LNG PK parameters were obtained via serum samples through an indwelling catheter at 0, 0.5, 1, 1.5, 2, and 2.5 h. The primary outcome was the difference in total and free LNG concentration maximum (Cmax) between ECx1 and ECx2 in the obese group. Results A total of 10 women enrolled and completed the study (normal BMI = 5, median 22.8 kg/m2, range 20.8-23.7; obese BMI = 5, 39.5 kg/m2, range 35.9-46.7). The total LNG Cmax for obese subjects following ECx1 (5.57 ± 2.48 ng/mL) was significantly lower than the level observed in normal BMI women (10.30 ± 2.47, p =.027). Notably, ECx2 increased the Cmax significantly (10.52 ± 2.76, p =.002); approximating the level in normal BMI subjects receiving ECx1. Free LNG Cmax followed a similar pattern. Conclusion Obesity adversely impacts both the total and free Cmax levels of LNG EC and this likely explains its lack of efficacy in obese women. Doubling the dose appears to correct the obesity-related PK changes but additional research is needed to determine if this also improves EC effectiveness in obese women. Implications This study demonstrates that obesity interferes with the pharmacokinetics of LNG EC, and that doubling the dose may be an effective strategy to improve its efficacy in obese women.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalContraception
Volume94
Issue number1
DOIs
StatePublished - Jul 1 2016

Keywords

  • body weight
  • emergency contraception
  • obesity
  • pharmacokinetics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: Single and double dosing'. Together they form a unique fingerprint.

  • Cite this