Impact of maternal obesity on fetal programming of cardiovascular disease

Victoria H.J. Roberts, Antonio E. Frias, Kevin L. Grove

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalPhysiology
Volume30
Issue number3
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Physiology

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