Impact of maternal obesity on fetal programming of cardiovascular disease

Victoria H.J. Roberts; Antonio E. Frias; Kevin L. Grove

doi:10.1152/physiol.00021.2014

Impact of maternal obesity on fetal programming of cardiovascular disease

Victoria H.J. Roberts, Antonio E. Frias, Kevin L. Grove

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.

Original language	English (US)
Pages (from-to)	224-231
Number of pages	8
Journal	Physiology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1152/physiol.00021.2014
State	Published - 2015

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00021.2014

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title = "Impact of maternal obesity on fetal programming of cardiovascular disease",

abstract = "The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.",

author = "Roberts, {Victoria H.J.} and Frias, {Antonio E.} and Grove, {Kevin L.}",

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AB - The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.

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Impact of maternal obesity on fetal programming of cardiovascular disease

Abstract

ASJC Scopus subject areas

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