Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma

Koji Matsuo, Kwong Kwok Wong, Christina Fotopoulou, Erin A. Blake, Sharon E. Robertson, Tanja Pejovic, Marina Frimer, Vishakha Pardeshi, Wei Hu, Jong Sun Choi, Charlotte C. Sun, Abby M. Richmond, Jenna Z. Marcus, Maren A.M. Hilliard, Sayedamin Mostofizadeh, Paulette Mhawech-Fauceglia, Eman Abdulfatah, Miriam D. Post, Ozlen Saglam, Mian M.K. ShahzadRouzan G. Karabakhtsian, Rouba Ali-Fehmi, Hani Gabra, Lynda D. Roman, Anil K. Sood, David M. Gershenson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Objectives: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. Methods: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. Results: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047). Conclusion: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.

Original languageEnglish (US)
Pages (from-to)236-244
Number of pages9
JournalJournal of Surgical Oncology
Volume117
Issue number2
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

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Blood Vessels
Carcinoma
Survival
Neoplasms
Odds Ratio
Confidence Intervals
Disease-Free Survival
Lymph Nodes
Ascites
Multicenter Studies
Retrospective Studies
Neoplasm Metastasis
Recurrence

Keywords

  • low-grade serous
  • lymphovascular space invasion
  • ovarian cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma. / Matsuo, Koji; Wong, Kwong Kwok; Fotopoulou, Christina; Blake, Erin A.; Robertson, Sharon E.; Pejovic, Tanja; Frimer, Marina; Pardeshi, Vishakha; Hu, Wei; Choi, Jong Sun; Sun, Charlotte C.; Richmond, Abby M.; Marcus, Jenna Z.; Hilliard, Maren A.M.; Mostofizadeh, Sayedamin; Mhawech-Fauceglia, Paulette; Abdulfatah, Eman; Post, Miriam D.; Saglam, Ozlen; Shahzad, Mian M.K.; Karabakhtsian, Rouzan G.; Ali-Fehmi, Rouba; Gabra, Hani; Roman, Lynda D.; Sood, Anil K.; Gershenson, David M.

In: Journal of Surgical Oncology, Vol. 117, No. 2, 01.02.2018, p. 236-244.

Research output: Contribution to journalArticle

Matsuo, K, Wong, KK, Fotopoulou, C, Blake, EA, Robertson, SE, Pejovic, T, Frimer, M, Pardeshi, V, Hu, W, Choi, JS, Sun, CC, Richmond, AM, Marcus, JZ, Hilliard, MAM, Mostofizadeh, S, Mhawech-Fauceglia, P, Abdulfatah, E, Post, MD, Saglam, O, Shahzad, MMK, Karabakhtsian, RG, Ali-Fehmi, R, Gabra, H, Roman, LD, Sood, AK & Gershenson, DM 2018, 'Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma', Journal of Surgical Oncology, vol. 117, no. 2, pp. 236-244. https://doi.org/10.1002/jso.24801
Matsuo, Koji ; Wong, Kwong Kwok ; Fotopoulou, Christina ; Blake, Erin A. ; Robertson, Sharon E. ; Pejovic, Tanja ; Frimer, Marina ; Pardeshi, Vishakha ; Hu, Wei ; Choi, Jong Sun ; Sun, Charlotte C. ; Richmond, Abby M. ; Marcus, Jenna Z. ; Hilliard, Maren A.M. ; Mostofizadeh, Sayedamin ; Mhawech-Fauceglia, Paulette ; Abdulfatah, Eman ; Post, Miriam D. ; Saglam, Ozlen ; Shahzad, Mian M.K. ; Karabakhtsian, Rouzan G. ; Ali-Fehmi, Rouba ; Gabra, Hani ; Roman, Lynda D. ; Sood, Anil K. ; Gershenson, David M. / Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma. In: Journal of Surgical Oncology. 2018 ; Vol. 117, No. 2. pp. 236-244.
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abstract = "Background and Objectives: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. Methods: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. Results: LVSI was seen in 79 cases (44.4{\%}, 95{\%} confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0{\%} vs 64.9{\%}, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9{\%} vs 0{\%}, P = 0.012), and malignant ascites (49.3{\%} vs 32.6{\%}, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0{\%} vs 35.7{\%}, adjusted-hazard ratio 1.57, 95{\%}CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95{\%}CI 1.08-6.35, P = 0.047). Conclusion: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.",
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T1 - Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma

AU - Matsuo, Koji

AU - Wong, Kwong Kwok

AU - Fotopoulou, Christina

AU - Blake, Erin A.

AU - Robertson, Sharon E.

AU - Pejovic, Tanja

AU - Frimer, Marina

AU - Pardeshi, Vishakha

AU - Hu, Wei

AU - Choi, Jong Sun

AU - Sun, Charlotte C.

AU - Richmond, Abby M.

AU - Marcus, Jenna Z.

AU - Hilliard, Maren A.M.

AU - Mostofizadeh, Sayedamin

AU - Mhawech-Fauceglia, Paulette

AU - Abdulfatah, Eman

AU - Post, Miriam D.

AU - Saglam, Ozlen

AU - Shahzad, Mian M.K.

AU - Karabakhtsian, Rouzan G.

AU - Ali-Fehmi, Rouba

AU - Gabra, Hani

AU - Roman, Lynda D.

AU - Sood, Anil K.

AU - Gershenson, David M.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and Objectives: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. Methods: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. Results: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047). Conclusion: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.

AB - Background and Objectives: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. Methods: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. Results: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047). Conclusion: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.

KW - low-grade serous

KW - lymphovascular space invasion

KW - ovarian cancer

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