Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes

Hwa Mu Lee, Yanglu Zhao, Michael A. Liu, David Yanez, Mercedes Carnethon, R. Graham Barr, Nathan D. Wong

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Individuals with metabolic syndrome (MetS) and diabetes (DM) are more likely to have decreased lung function and are at greater risk of cardiovascular disease (CVD). Hypothesis.: Lung-function measures can predict CVD events in older persons with MetS, DM, and neither condition. Methods: We followed 4114 participants age ≥ 65 years with and without MetS or DM in the Cardiovascular Health Study. Cox regression examined the association of forced vital capacity (FVC) and 1-second forced expiratory volume (FEV1; percent of predicted values) with incident coronary heart disease and CVD events over 12.9 years. Results: DM was present in 537 (13.1%) and MetS in 1277 (31.0%) participants. Comparing fourth vs first quartiles for FVC, risk of CVD events was 16% (HR: 0.84, 95% CI: 0.59–1.18), 23% (HR: 0.77, 95% CI: 0.60–0.99), and 30% (HR: 0.70, 95% CI: 0.58–0.84) lower in DM, MetS, and neither disease groups, respectively. For FEV1, CVD risk was lower by 2% (HR: 0.98, 95% CI: 0.70–1.37), 26% (HR: 0.74, 95% CI: 0.59–0.93), and 31% (HR: 0.69, 95% CI: 0.57–0.82) in DM. Findings were strongest for predicting congestive heart failure (CHF) in all disease groups. C-statistics increased significantly with addition of FEV1 or FVC over risk factors for CVD and CHF among those with neither MetS nor DM. Conclusions: FEV1 and FVC are inversely related to CVD in older adults with and without MetS, but not DM (except for CHF); however, their value in incremental risk prediction beyond standard risk factors is limited mainly to metabolically healthier persons.

Original languageEnglish (US)
Pages (from-to)959-965
Number of pages7
JournalClinical Cardiology
Issue number7
StatePublished - Jul 2018


  • Cardiovascular
  • Cox Regression
  • Diabetes
  • Lung Function
  • Metabolic Syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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