Impact of infection or vaccination on pre-existing serological memory

Ian J. Amanna, Erika Hammarlund, Mathew W. Lewis, Mark K. Slifka

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3. years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.

    Original languageEnglish (US)
    Pages (from-to)1082-1086
    Number of pages5
    JournalHuman Immunology
    Volume73
    Issue number11
    DOIs
    StatePublished - Nov 1 2012

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    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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