Impact of fibrinogen levels on angiographic progression and 12-year survival in the armed forces regression study

Ganesh P. Devendra, Stephen A. Hart, Edwin J. Whitney, Richard A. Krasuski

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We assessed the role of fibrinogen levels on angiographic progression and long-term survival among 111 patients with coronary disease enrolled in the Armed Forces Regression Study (AFREGS). Baseline fibrinogen levels and quantitative coronary angiography were performed initially and at 30 months. Progression or nonregression of coronary disease was more prevalent in patients with high fibrinogen than patients with normal fibrinogen (66.1% vs 45.5%; P =.022). Twelve-year cardiovascular (CV) mortality was substantially higher if fibrinogen was elevated (17.9% vs 3.6%, P =.016). Among patients with elevated fibrinogen and angiographic progression or nonregression, there were 10 deaths and all were CV. Elevated levels of fibrinogen predict the angiographic progression of existing coronary disease and likelihood of CV death. Among patients with elevated levels of fibrinogen, angiographic progression identifies a significantly increased likelihood of a fatal CV event.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalAngiology
Volume61
Issue number4
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Angiographic progression
  • Atherosclerosis
  • Fibrinogen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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