Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients

Ranbir Chander Sobti, Nega Berhane, Salih Abdul Mahdi, Rupinder Kler, Seyed Ali Hosseini, Vijish Kuttiat, Ajay Wanchu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2 Lyc751Gln (excision repair cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility and disease progression to AIDS, as this gene has been reported to intervene in degrading retroviral cDNA before it integrates with the host DNA. This case control study included 300 HIV seropositive cases and an equal number of HIV seronegative controls. DNA was isolated from the blood samples of study subjects and genotyping of ERCC2 was conducted by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. The Gln/Gln genotype showed a significant variation between cases and controls (P = 0.047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases.

Original languageEnglish (US)
Pages (from-to)2945-2952
Number of pages8
JournalMolecular Biology Reports
Volume38
Issue number5
DOIs
StatePublished - Jun 1 2011

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Keywords

  • Disease progression
  • ERCC2 polymorphism
  • HIV 1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Sobti, R. C., Berhane, N., Mahdi, S. A., Kler, R., Hosseini, S. A., Kuttiat, V., & Wanchu, A. (2011). Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients. Molecular Biology Reports, 38(5), 2945-2952. https://doi.org/10.1007/s11033-010-9958-8