Impact of enhanced recovery after cesarean delivery on maternal outcomes: A systematic review and meta-analysis

Pervez Sultan, Nadir Sharawi, Lindsay Blake, Ashraf S. Habib, Kathleen F. Brookfield, Brendan Carvalho

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: This meta-analysis explores the impact of enhanced recovery after cesarean delivery (ERAC) on maternal outcomes. Methods: We searched 4 databases (Web of Science, Embase, PubMed and CINAHL) in October 2020 without date limiters, for studies quantitatively comparing ERAC implementation to a control group. The primary outcome was length of hospital stay and secondary outcomes included time to mobilization and time to urinary catheter removal, opioid consumption, readmission rates and cost savings. Mean differences and odds ratios (MD and OR with 95% confidence intervals) were calculated. Levels of evidence were assessed using GRADE. Results: Twelve studies involving 17,607 patients (9693 without ERAC and 7914 with ERAC) were included. ERAC was associated with reduced: length of hospital stay (MD −0.51 days [−0.94, −0.09]; p = 0.018; I2 = 99%), time to first mobilization (MD −11.05 h [−18.64, −3.46]; p = 0.004; I2 = 98%), time to urinary catheter removal (MD −13.19 h [−17.59, −8.79]; p < 0.001; I2 = 97%) and opioid consumption (MD -21.85 mg morphine equivalents [−33.19, −10.50]; p = < 0.001; I2 = 91%), with no difference in maternal readmission rate (OR 1.23 [0.96, 1.57]; p = 0.10; I2 = 0%). Three studies reported cost savings associated with ERAC. The GRADE levels of evidence were rated as low or very low quality for all study outcomes. Conclusion: ERAC is associated with reduction in length of stay, times to first mobilization and urinary catheter removal and opioid consumption. ERAC does not significantly affect maternal hospital readmission rates following discharge. Further studies are required to determine which ERAC interventions to implement and which outcomes best determine ERAC efficacy.

Original languageEnglish (US)
Article number100935
JournalAnnales Francaises d'Anesthesie et de Reanimation
Volume40
Issue number5
DOIs
StatePublished - Oct 2021

Keywords

  • Cesarean
  • ERAC
  • ERAS
  • Enhanced recovery
  • Recovery

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

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