Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC)

Ashley Galloway; Yojin Park; Vidisha Tanukonda; Yuk Lam Ho; Xuan Mai T. Nguyen; Monika Maripuri; Andrew T. Dey; Hanna Gerlovin; Daniel Posner; Kristine E. Lynch; Tianxi Cai; Shiuh Wen Luoh; Stacey Whitbourne; David R. Gagnon; Sumitra Muralidhar; Phillip S. Tsao; Juan P. Casas; J. Michael Gaziano; Peter W.F. Wilson; Adriana M. Hung; Kelly Cho

doi:10.1093/infdis/jiac182

Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC)

Ashley Galloway, Yojin Park, Vidisha Tanukonda, Yuk Lam Ho, Xuan Mai T. Nguyen, Monika Maripuri, Andrew T. Dey, Hanna Gerlovin, Daniel Posner, Kristine E. Lynch, Tianxi Cai, Shiuh Wen Luoh, Stacey Whitbourne, David R. Gagnon, Sumitra Muralidhar, Phillip S. Tsao, Juan P. Casas, J. Michael Gaziano, Peter W.F. Wilson, Adriana M. HungKelly Cho

Hematology & Medical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

In this retrospective cohort study of 94 595 severe acute respiratory syndrome coronavirus 2-positive cases, we developed and validated an algorithm to assess the association between coronavirus disease 2019 (COVID-19) severity and long-term complications (stroke, myocardial infarction, pulmonary embolism/deep vein thrombosis, heart failure, and mortality). COVID-19 severity was associated with a greater risk of experiencing a long-term complication 31-120 days postinfection. Most incident events occurred 31-60 days postinfection and diminished after day 91, except heart failure for severe patients and death for moderate patients, which peaked on days 91-120. Understanding the differential impact of COVID-19 severity on long-term events provides insight into possible intervention modalities and critical prevention strategies.

Original language	English (US)
Pages (from-to)	2113-2117
Number of pages	5
Journal	The Journal of infectious diseases
Volume	226
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiac182
State	Published - Dec 13 2022

Keywords

COVID-19
EHR
electronic health records
epidemiology
SARS-CoV-2
Veterans

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiac182

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Galloway, A., Park, Y., Tanukonda, V., Ho, Y. L., Nguyen, X. M. T., Maripuri, M., Dey, A. T., Gerlovin, H., Posner, D., Lynch, K. E., Cai, T., Luoh, S. W., Whitbourne, S., Gagnon, D. R., Muralidhar, S., Tsao, P. S., Casas, J. P., Gaziano, J. M., Wilson, P. W. F., ... Cho, K. (2022). Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC). The Journal of infectious diseases, 226(12), 2113-2117. https://doi.org/10.1093/infdis/jiac182

Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC). / Galloway, Ashley; Park, Yojin; Tanukonda, Vidisha et al.

In: The Journal of infectious diseases, Vol. 226, No. 12, 13.12.2022, p. 2113-2117.

Research output: Contribution to journal › Article › peer-review

Galloway, A, Park, Y, Tanukonda, V, Ho, YL, Nguyen, XMT, Maripuri, M, Dey, AT, Gerlovin, H, Posner, D, Lynch, KE, Cai, T, Luoh, SW, Whitbourne, S, Gagnon, DR, Muralidhar, S, Tsao, PS, Casas, JP, Gaziano, JM, Wilson, PWF, Hung, AM & Cho, K 2022, 'Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC)', The Journal of infectious diseases, vol. 226, no. 12, pp. 2113-2117. https://doi.org/10.1093/infdis/jiac182

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title = "Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC)",

abstract = "In this retrospective cohort study of 94 595 severe acute respiratory syndrome coronavirus 2-positive cases, we developed and validated an algorithm to assess the association between coronavirus disease 2019 (COVID-19) severity and long-term complications (stroke, myocardial infarction, pulmonary embolism/deep vein thrombosis, heart failure, and mortality). COVID-19 severity was associated with a greater risk of experiencing a long-term complication 31-120 days postinfection. Most incident events occurred 31-60 days postinfection and diminished after day 91, except heart failure for severe patients and death for moderate patients, which peaked on days 91-120. Understanding the differential impact of COVID-19 severity on long-term events provides insight into possible intervention modalities and critical prevention strategies.",

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author = "Ashley Galloway and Yojin Park and Vidisha Tanukonda and Ho, {Yuk Lam} and Nguyen, {Xuan Mai T.} and Monika Maripuri and Dey, {Andrew T.} and Hanna Gerlovin and Daniel Posner and Lynch, {Kristine E.} and Tianxi Cai and Luoh, {Shiuh Wen} and Stacey Whitbourne and Gagnon, {David R.} and Sumitra Muralidhar and Tsao, {Phillip S.} and Casas, {Juan P.} and Gaziano, {J. Michael} and Wilson, {Peter W.F.} and Hung, {Adriana M.} and Kelly Cho",

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doi = "10.1093/infdis/jiac182",

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AU - Park, Yojin

AU - Tanukonda, Vidisha

AU - Ho, Yuk Lam

AU - Nguyen, Xuan Mai T.

AU - Maripuri, Monika

AU - Dey, Andrew T.

AU - Gerlovin, Hanna

AU - Posner, Daniel

AU - Lynch, Kristine E.

AU - Cai, Tianxi

AU - Luoh, Shiuh Wen

AU - Whitbourne, Stacey

AU - Gagnon, David R.

AU - Muralidhar, Sumitra

AU - Tsao, Phillip S.

AU - Casas, Juan P.

AU - Gaziano, J. Michael

AU - Wilson, Peter W.F.

AU - Hung, Adriana M.

AU - Cho, Kelly

N1 - Publisher Copyright: Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

PY - 2022/12/13

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N2 - In this retrospective cohort study of 94 595 severe acute respiratory syndrome coronavirus 2-positive cases, we developed and validated an algorithm to assess the association between coronavirus disease 2019 (COVID-19) severity and long-term complications (stroke, myocardial infarction, pulmonary embolism/deep vein thrombosis, heart failure, and mortality). COVID-19 severity was associated with a greater risk of experiencing a long-term complication 31-120 days postinfection. Most incident events occurred 31-60 days postinfection and diminished after day 91, except heart failure for severe patients and death for moderate patients, which peaked on days 91-120. Understanding the differential impact of COVID-19 severity on long-term events provides insight into possible intervention modalities and critical prevention strategies.

AB - In this retrospective cohort study of 94 595 severe acute respiratory syndrome coronavirus 2-positive cases, we developed and validated an algorithm to assess the association between coronavirus disease 2019 (COVID-19) severity and long-term complications (stroke, myocardial infarction, pulmonary embolism/deep vein thrombosis, heart failure, and mortality). COVID-19 severity was associated with a greater risk of experiencing a long-term complication 31-120 days postinfection. Most incident events occurred 31-60 days postinfection and diminished after day 91, except heart failure for severe patients and death for moderate patients, which peaked on days 91-120. Understanding the differential impact of COVID-19 severity on long-term events provides insight into possible intervention modalities and critical prevention strategies.

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Impact of Coronavirus Disease 2019 (COVID-19) Severity on Long-term Events in United States Veterans Using the Veterans Affairs Severity Index for COVID-19 (VASIC)

Abstract

Keywords

ASJC Scopus subject areas

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