Impact of adjuvant external beam radiotherapy on survival in surgically resected gallbladder adenocarcinoma: A propensity score-matched Surveillance, Epidemiology, and End Results analysis

Omar Hyder, Rebecca M. Dodson, Teviah Sachs, Matthew Weiss, Skye Mayo, Michael A. Choti, Christopher L. Wolfgang, Joseph M. Herman, Timothy M. Pawlik

Research output: Contribution to journalArticle

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Abstract

Background. We sought to define the utilization and effect of adjuvant external-beam radiotherapy (XRT) on patients having undergone curative-intent resection for gallbladder cancer (GBC). Methods. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 5,011 patients with GBC who underwent resection between 1988 and 2009. The impact of XRT on survival was analyzed by the use of propensity-score matching by comparing clinicopathologic factors between patients who received resection only versus resection plus XRT. Results. Median age was 72 years, and most patients were female (73.4%); 66.2% patients had intermediate to poorly differentiated tumors, and 19.1% had lymph node metastasis. The majority (75.0%) had ''localized'' disease by Surveillance, Epidemiology, and End Results classification. A total of 899 patients (17.9%) received XRT whereas 4,112 patients did not. Factors associated with receipt of XRT were younger age (odds ratio [OR] 5.33), tumor extension beyond the serosa (OR 1.55), intermediate- to poorly differentiated tumors (OR 1.56), and lymph node metastasis (OR 2.59) (all P

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalSurgery (United States)
Volume155
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

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Propensity Score
Gallbladder
Epidemiology
Adenocarcinoma
Radiotherapy
Survival
Odds Ratio
Gallbladder Neoplasms
Lymph Nodes
Neoplasm Metastasis
Serous Membrane
Neoplasms
Databases

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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Impact of adjuvant external beam radiotherapy on survival in surgically resected gallbladder adenocarcinoma : A propensity score-matched Surveillance, Epidemiology, and End Results analysis. / Hyder, Omar; Dodson, Rebecca M.; Sachs, Teviah; Weiss, Matthew; Mayo, Skye; Choti, Michael A.; Wolfgang, Christopher L.; Herman, Joseph M.; Pawlik, Timothy M.

In: Surgery (United States), Vol. 155, No. 1, 2014, p. 85-93.

Research output: Contribution to journalArticle

Hyder, Omar ; Dodson, Rebecca M. ; Sachs, Teviah ; Weiss, Matthew ; Mayo, Skye ; Choti, Michael A. ; Wolfgang, Christopher L. ; Herman, Joseph M. ; Pawlik, Timothy M. / Impact of adjuvant external beam radiotherapy on survival in surgically resected gallbladder adenocarcinoma : A propensity score-matched Surveillance, Epidemiology, and End Results analysis. In: Surgery (United States). 2014 ; Vol. 155, No. 1. pp. 85-93.
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abstract = "Background. We sought to define the utilization and effect of adjuvant external-beam radiotherapy (XRT) on patients having undergone curative-intent resection for gallbladder cancer (GBC). Methods. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 5,011 patients with GBC who underwent resection between 1988 and 2009. The impact of XRT on survival was analyzed by the use of propensity-score matching by comparing clinicopathologic factors between patients who received resection only versus resection plus XRT. Results. Median age was 72 years, and most patients were female (73.4{\%}); 66.2{\%} patients had intermediate to poorly differentiated tumors, and 19.1{\%} had lymph node metastasis. The majority (75.0{\%}) had ''localized'' disease by Surveillance, Epidemiology, and End Results classification. A total of 899 patients (17.9{\%}) received XRT whereas 4,112 patients did not. Factors associated with receipt of XRT were younger age (odds ratio [OR] 5.33), tumor extension beyond the serosa (OR 1.55), intermediate- to poorly differentiated tumors (OR 1.56), and lymph node metastasis (OR 2.59) (all P",
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AU - Herman, Joseph M.

AU - Pawlik, Timothy M.

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N2 - Background. We sought to define the utilization and effect of adjuvant external-beam radiotherapy (XRT) on patients having undergone curative-intent resection for gallbladder cancer (GBC). Methods. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 5,011 patients with GBC who underwent resection between 1988 and 2009. The impact of XRT on survival was analyzed by the use of propensity-score matching by comparing clinicopathologic factors between patients who received resection only versus resection plus XRT. Results. Median age was 72 years, and most patients were female (73.4%); 66.2% patients had intermediate to poorly differentiated tumors, and 19.1% had lymph node metastasis. The majority (75.0%) had ''localized'' disease by Surveillance, Epidemiology, and End Results classification. A total of 899 patients (17.9%) received XRT whereas 4,112 patients did not. Factors associated with receipt of XRT were younger age (odds ratio [OR] 5.33), tumor extension beyond the serosa (OR 1.55), intermediate- to poorly differentiated tumors (OR 1.56), and lymph node metastasis (OR 2.59) (all P

AB - Background. We sought to define the utilization and effect of adjuvant external-beam radiotherapy (XRT) on patients having undergone curative-intent resection for gallbladder cancer (GBC). Methods. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 5,011 patients with GBC who underwent resection between 1988 and 2009. The impact of XRT on survival was analyzed by the use of propensity-score matching by comparing clinicopathologic factors between patients who received resection only versus resection plus XRT. Results. Median age was 72 years, and most patients were female (73.4%); 66.2% patients had intermediate to poorly differentiated tumors, and 19.1% had lymph node metastasis. The majority (75.0%) had ''localized'' disease by Surveillance, Epidemiology, and End Results classification. A total of 899 patients (17.9%) received XRT whereas 4,112 patients did not. Factors associated with receipt of XRT were younger age (odds ratio [OR] 5.33), tumor extension beyond the serosa (OR 1.55), intermediate- to poorly differentiated tumors (OR 1.56), and lymph node metastasis (OR 2.59) (all P

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