Impact of acute biochemical castration on insulin sensitivity in healthy adult men

Atoosa Rabiee, Andrew A. Dwyer, Lisa M. Caronia, Frances J. Hayes, Maria A. Yialamas, Dana Andersen, Bijoy Thomas, Martin Torriani, Dariush Elahi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction. Evidence supports an inverse relationship between serum testosterone (T) and insulin resistance in men. However, data with respect to causality are limited. The aim of this study was to explore the impact of acute biochemical castration on insulin sensitivity in healthy adult men. Methods. Ten healthy, adult males (mean age 41.0 ± 3.9 yr) were studied. Subjects were studied at baseline and after 2 and 4 weeks of biochemical castration. Outpatient hospital research setting. Body composition (dual-energy X-ray absorptiometry), energy expenditure (indirect calorimetry), abdominal and visceral adiposity (MRI), skeletal muscle intramyocellular lipid content ([IMCL] 1H-MR spectroscopy), and insulin sensitivity (hyperinsulinemic-euglycemic clamp) were assessed before and after 2 and 4 weeks of biochemical castration induced by a GnRH antagonist (acyline 300 μg/kg subcutaneous every 10-14 days). Serum T, insulin and glucose levels, body composition, abdominal visceral fat, IMCL, and glucose disposal rate (M) were measured. Results and Conclusion. Acyline administration suppressed serum T to frankly hypogonadal levels in all subjects for the duration of the study (P

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalEndocrine Research
Volume35
Issue number2
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Castration
Insulin Resistance
Body Composition
Serum
Lipids
Glucose
Indirect Calorimetry
Glucose Clamp Technique
Intra-Abdominal Fat
Photon Absorptiometry
Adiposity
Gonadotropin-Releasing Hormone
Causality
Energy Metabolism
Testosterone
Skeletal Muscle
Outpatients
Magnetic Resonance Spectroscopy
Insulin
Research

Keywords

  • Body Composition
  • Insulin Sensitivity
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology

Cite this

Rabiee, A., Dwyer, A. A., Caronia, L. M., Hayes, F. J., Yialamas, M. A., Andersen, D., ... Elahi, D. (2010). Impact of acute biochemical castration on insulin sensitivity in healthy adult men. Endocrine Research, 35(2), 71-84. https://doi.org/10.3109/07435801003705601

Impact of acute biochemical castration on insulin sensitivity in healthy adult men. / Rabiee, Atoosa; Dwyer, Andrew A.; Caronia, Lisa M.; Hayes, Frances J.; Yialamas, Maria A.; Andersen, Dana; Thomas, Bijoy; Torriani, Martin; Elahi, Dariush.

In: Endocrine Research, Vol. 35, No. 2, 05.2010, p. 71-84.

Research output: Contribution to journalArticle

Rabiee, A, Dwyer, AA, Caronia, LM, Hayes, FJ, Yialamas, MA, Andersen, D, Thomas, B, Torriani, M & Elahi, D 2010, 'Impact of acute biochemical castration on insulin sensitivity in healthy adult men', Endocrine Research, vol. 35, no. 2, pp. 71-84. https://doi.org/10.3109/07435801003705601
Rabiee, Atoosa ; Dwyer, Andrew A. ; Caronia, Lisa M. ; Hayes, Frances J. ; Yialamas, Maria A. ; Andersen, Dana ; Thomas, Bijoy ; Torriani, Martin ; Elahi, Dariush. / Impact of acute biochemical castration on insulin sensitivity in healthy adult men. In: Endocrine Research. 2010 ; Vol. 35, No. 2. pp. 71-84.
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