Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis

Arthur Vandenbark, Bruce L. Gibbins, David J. Hinrichs

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCellular Immunology
Volume11
Issue number1-3
DOIs
StatePublished - Mar 30 1974
Externally publishedYes

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Alpha-Globulins
Autoimmune Experimental Encephalomyelitis
Immunosuppressive Agents
Serum
Immune System Diseases
Mitogens
Thymidine
Central Nervous System
Lymphocytes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis. / Vandenbark, Arthur; Gibbins, Bruce L.; Hinrichs, David J.

In: Cellular Immunology, Vol. 11, No. 1-3, 30.03.1974, p. 1-10.

Research output: Contribution to journalArticle

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