Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis

Arthur A. Vandenbark, Bruce L. Gibbins, David J. Hinrichs

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCellular Immunology
Volume11
Issue number1-3
DOIs
StatePublished - Mar 30 1974

ASJC Scopus subject areas

  • Immunology

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