Immunosuppression follows systemic T lymphocyte activation in the burn patient

J. A. TEODORCZYK‐INJEYAN, B. G. SPARKES, Gordon Mills, W. J. PETERS

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A general consensus that thermal injury affects T lymphocyte function adversely is supported particularly by the observation that burned patients’ lymphocytes secrete reduced levels of biologically active IL‐2 in vitro. In the same patients, however, high serum concentrations of the low‐affinity IL‐2 receptor (IL2Rα), a product of an IL‐2‐activated gene, have been observed. In this study a significant proportion of patients also demonstrated over‐physiological levels (from 2 to 500 U/ml) of serum IL‐2 ascertained by immunoassay. Increases in serum IL‐2 content correlated significantly (P < 002) with those of serum IL‐2Rα during the first week post‐burn. Later, serum IL‐2Rα levels continued to increase up to 30 days while IL‐2 eventually declined. Thus, augmented secretion of IL‐2Rα appears related to the high serum IL‐2 content. Therefore refractoriness to further immune stimulation may be due to early activation of the lymphoid system, rather than to an intrinsic incapacity of T lymphocytes for generating sequential responses.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalClinical & Experimental Immunology
Volume85
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Lymphocyte Activation
Immunosuppression
Interleukin-2 Receptors
Interleukin-2
T-Lymphocytes
Serum
Immunoassay
Hot Temperature
Lymphocytes
Wounds and Injuries
Genes

Keywords

  • burn immunosuppression
  • IL‐2
  • IL‐2 receptor
  • T cell activation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunosuppression follows systemic T lymphocyte activation in the burn patient. / TEODORCZYK‐INJEYAN, J. A.; SPARKES, B. G.; Mills, Gordon; PETERS, W. J.

In: Clinical & Experimental Immunology, Vol. 85, No. 3, 01.01.1991, p. 515-518.

Research output: Contribution to journalArticle

TEODORCZYK‐INJEYAN, J. A. ; SPARKES, B. G. ; Mills, Gordon ; PETERS, W. J. / Immunosuppression follows systemic T lymphocyte activation in the burn patient. In: Clinical & Experimental Immunology. 1991 ; Vol. 85, No. 3. pp. 515-518.
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