Immunosuppression by canine distemper virus: Modulation of in vitro immunoglobulin synthesis, interleukin release and prostaglandin E2 production

Steven Krakowka, Susan S. Ringler, Mark Lewis, Richard G. Olsen, Michael K. Axthelm

    Research output: Contribution to journalArticle

    30 Scopus citations

    Abstract

    In vitro or in vivo infection of canine mononuclear cells by canine distemper virus (CDV) in short-term microcultures resulted in suppression of lectin-induced 3H-thymidine incorporation. This suppressive effect was also evident in pokeweed mitogen-driven in vitro immunoglobulin synthesis and release. Lectin-induced interleukin-2 production by monocyte-depleted lymphocyte cultures was marginally affected by CDV, whereas interleukin-1 production by adherent mononuclear cells was significantly depressed. Monocyte cultures established from viremic dogs released prostaglandin (PG)E2. The results suggest that, in addition to a direct viral effect upon lectin responsive cellular population(s), CDV modulates monocyte functions by inhibition of interleukin-1 production and by enhancing PGE2 release.

    Original languageEnglish (US)
    Pages (from-to)181-201
    Number of pages21
    JournalVeterinary Immunology and Immunopathology
    Volume15
    Issue number3
    DOIs
    StatePublished - Jun 1987

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    ASJC Scopus subject areas

    • Immunology
    • veterinary(all)

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