Immunoreactive ACTH in cerebrospinal fluid

J. P. Allen, John Kendall, R. McGilvra, C. Vancura

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

A previous report of the presence of ACTH in cerebrospinal fluid prompted an investigation of its concentration in the CSF of patients with nonendocrine disease and of the mechanism by which it enters this fluid. The mean immunoreactive ACTH concentration in 22 patients was 98 pg/ml which slightly, but not significantly, exceeded the mean concentration in simultaneously obtained plasma specimens (74 pg/ml). However, there was no correlation (r = 0.2) between the concentrations of individual pairs of ACTH values obtained from plasma and CSF. The transport of ACTH between the blood and CSF compartments was investigated in man and the cat. After 48 hr administration of exogenous ACTH in man, when the plasma concentration was very high, the CSF ACTH concentration remained low. During infusion of labeled ACTH in cats, a steadystate plasma/CSF radioactivity ratio was obtained after 4-6 hr, at which time the concentration of radioactivity attributable to labelled ACTH was 100 times higher in plasma than in CSF. These findings indicate that the blood CSF barrier is relatively impermeable to ACTH in man and the cat. The relatively high CSF ACTH concentrations found in patients with nonendocrine disease suggests that some or most of the ACTH present in CSF may enter by a mechanism which bypasses the blood CSF barrier.

Original languageEnglish (US)
Pages (from-to)586-593
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number4
StatePublished - 1974

Fingerprint

Cerebrospinal fluid
Adrenocorticotropic Hormone
Cerebrospinal Fluid
Plasmas
Cats
Blood
Radioactivity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Allen, J. P., Kendall, J., McGilvra, R., & Vancura, C. (1974). Immunoreactive ACTH in cerebrospinal fluid. Journal of Clinical Endocrinology and Metabolism, 38(4), 586-593.

Immunoreactive ACTH in cerebrospinal fluid. / Allen, J. P.; Kendall, John; McGilvra, R.; Vancura, C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 38, No. 4, 1974, p. 586-593.

Research output: Contribution to journalArticle

Allen, JP, Kendall, J, McGilvra, R & Vancura, C 1974, 'Immunoreactive ACTH in cerebrospinal fluid', Journal of Clinical Endocrinology and Metabolism, vol. 38, no. 4, pp. 586-593.
Allen JP, Kendall J, McGilvra R, Vancura C. Immunoreactive ACTH in cerebrospinal fluid. Journal of Clinical Endocrinology and Metabolism. 1974;38(4):586-593.
Allen, J. P. ; Kendall, John ; McGilvra, R. ; Vancura, C. / Immunoreactive ACTH in cerebrospinal fluid. In: Journal of Clinical Endocrinology and Metabolism. 1974 ; Vol. 38, No. 4. pp. 586-593.
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