Immunophenotypic variations of Burkitt lymphoma

Katalin Kelemen, Rita Braziel, Ken Gatter, Tony C. Bakke, Susan Olson, Guang Fan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Burkitt lymphoma (BL) exhibits a characteristic immunophenotype that is positive for pan-B-cell antigens and CD10 and expresses clonal surface immunoglobulins (SIgs). We evaluated 35 BLs and identified atypical immunophenotypes in 4 including SIg light chain negativity in 4, negativity for B-cell antigens in 2, lack of CD10 in 1, and CD4 expression in 1. All 4 cases showed morphologic features characteristic of BL, and all were confirmed by cytogenetic analysis. The 4 BL cases included 1 girl, 2 men with HIV/AIDS, and a third man with a history of heart transplantation. Two patients died shortly after diagnosis; the other 2 completed hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone with highly active antiretroviral therapy and achieved complete remission. Our study indicates that an unusual immunophenotype is not uncommon in BL. If the immunophenotype is interpreted in isolation, the diagnosis could be missed. Recognizing the variability of immunophenotype is essential for establishing an accurate diagnosis of BL.

Original languageEnglish (US)
Pages (from-to)127-138
Number of pages12
JournalAmerican Journal of Clinical Pathology
Volume134
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Burkitt Lymphoma
B-Lymphocytes
Neprilysin
B-Cell Antigen Receptors
Cytogenetic Analysis
Highly Active Antiretroviral Therapy
Vincristine
Heart Transplantation
Doxorubicin
Cyclophosphamide
Dexamethasone
Acquired Immunodeficiency Syndrome
HIV
Light
Antigens

Keywords

  • Aberrant immunophenotype
  • Burkitt lymphoma
  • Flow cytometry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunophenotypic variations of Burkitt lymphoma. / Kelemen, Katalin; Braziel, Rita; Gatter, Ken; Bakke, Tony C.; Olson, Susan; Fan, Guang.

In: American Journal of Clinical Pathology, Vol. 134, No. 1, 07.2010, p. 127-138.

Research output: Contribution to journalArticle

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