Immunopharmacology of the atopic diseases

Jon Hanifin, J. M. Butler, S. C. Chan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The atopic conditions, atopic dermatitis, asthma, and allergic rhinitis, may arise as a result of infiltrating bone marrow-derived cells into skin or respiratory mucosae. Release of inflammatory factors from these cells could account for cutaneous vascular instability and pruritus in atopic dermatitis. Erythema and itch have been induced by experimental stress interviews and by blind food challenges. In the latter, increased plasma histamine was detected and correlated with cutaneous reactions. Basophils from patients with atopic dermatitis have increased histamine release after exposure to immunologic or nonimmunologic lectin stimuli. This increased releasability may relate to inadequate cyclic AMP regulation of cell function. We have found that leukocytes of patients with atopic dermatitis have elevated phosphodiesterase activity and consequently reduced intracellular cyclic AMP. Exposure of the cells to a phosphodiesterase inhibitor caused considerable reduction in histamine release. Similarly, exposure of atopic B lymphocytes to a phosphodiesterase inhibitor greatly reduced the high spontaneous IgE synthesis in mononuclear leukocyte cultures. Elevated leukocyte phosphodiesterase activity may also serve as a marker for the atopic diathesis. We have found elevated enzyme activity in umbilical cord blood from newborns with atopic parents, suggesting that this defect may relate to a genetically determined defect. These studies have provided insight into basic abnormalities associated with atopic dermatitis and the atopic diathesis. Defects of regulatory mechanisms in immune and inflammatory cells may help explain the seemingly disparate disorders of physiologic, pharmacologic, and immunologic systems in atopy.

Original languageEnglish (US)
JournalJournal of Investigative Dermatology
Volume85
Issue numberSUPPL. 1
StatePublished - 1985

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Atopic Dermatitis
Histamine
Phosphodiesterase Inhibitors
Histamine Release
Disease Susceptibility
Phosphoric Diester Hydrolases
Cyclic AMP
Skin
Defects
Leukocytes
Mononuclear Leukocytes
Respiratory Mucosa
Lymphocytes
Basophils
Enzyme activity
Erythema
Pruritus
Fetal Blood
Lectins
Bone Marrow Cells

ASJC Scopus subject areas

  • Dermatology

Cite this

Immunopharmacology of the atopic diseases. / Hanifin, Jon; Butler, J. M.; Chan, S. C.

In: Journal of Investigative Dermatology, Vol. 85, No. SUPPL. 1, 1985.

Research output: Contribution to journalArticle

Hanifin, J, Butler, JM & Chan, SC 1985, 'Immunopharmacology of the atopic diseases', Journal of Investigative Dermatology, vol. 85, no. SUPPL. 1.
Hanifin, Jon ; Butler, J. M. ; Chan, S. C. / Immunopharmacology of the atopic diseases. In: Journal of Investigative Dermatology. 1985 ; Vol. 85, No. SUPPL. 1.
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