Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair, Minsha Manoharan, Stephanie D. Rawlings-Rhea, Ian Tagge, Steven G. Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L. Woltjer, Meredith C. Frederick, James Pollaro, William D. Rooney, Larry S. Sherman, Dennis N. Bourdette, Scott W. Wong

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume291
DOIs
StatePublished - Feb 15 2016

Fingerprint

Encephalomyelitis
Macaca
Multiple Sclerosis
Central Nervous System
T-Lymphocytes
Interleukin-17
Immune System Diseases
Gadolinium
Demyelinating Diseases
Primates
Magnetic Resonance Imaging
Phenotype

Keywords

  • Demyelination
  • Inflammatory
  • Interleukin 17 (IL-17)
  • Intrathecal IgG
  • Magnetic resonance imaging (MRI)
  • Th1
  • Th17

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. / Blair, Tiffany C.; Manoharan, Minsha; Rawlings-Rhea, Stephanie D.; Tagge, Ian; Kohama, Steven G.; Hollister-Smith, Julie; Ferguson, Betsy; Woltjer, Randall L.; Frederick, Meredith C.; Pollaro, James; Rooney, William D.; Sherman, Larry S.; Bourdette, Dennis N.; Wong, Scott W.

In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 1-10.

Research output: Contribution to journalArticle

Blair TC, Manoharan M, Rawlings-Rhea SD, Tagge I, Kohama SG, Hollister-Smith J et al. Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. Journal of Neuroimmunology. 2016 Feb 15;291:1-10. Available from, DOI: 10.1016/j.jneuroim.2015.11.026

Blair, Tiffany C.; Manoharan, Minsha; Rawlings-Rhea, Stephanie D.; Tagge, Ian; Kohama, Steven G.; Hollister-Smith, Julie; Ferguson, Betsy; Woltjer, Randall L.; Frederick, Meredith C.; Pollaro, James; Rooney, William D.; Sherman, Larry S.; Bourdette, Dennis N.; Wong, Scott W. / Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis.

In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 1-10.

Research output: Contribution to journalArticle

@article{41f6f59fd19b4aeab7d8c90cb4c1b190,
title = "Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis",
abstract = "Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.",
keywords = "Demyelination, Inflammatory, Interleukin 17 (IL-17), Intrathecal IgG, Magnetic resonance imaging (MRI), Th1, Th17",
author = "Blair, {Tiffany C.} and Minsha Manoharan and Rawlings-Rhea, {Stephanie D.} and Ian Tagge and Kohama, {Steven G.} and Julie Hollister-Smith and Betsy Ferguson and Woltjer, {Randall L.} and Frederick, {Meredith C.} and James Pollaro and Rooney, {William D.} and Sherman, {Larry S.} and Bourdette, {Dennis N.} and Wong, {Scott W.}",
year = "2016",
month = "2",
doi = "10.1016/j.jneuroim.2015.11.026",
volume = "291",
pages = "1--10",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

TY - JOUR

T1 - Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

AU - Blair,Tiffany C.

AU - Manoharan,Minsha

AU - Rawlings-Rhea,Stephanie D.

AU - Tagge,Ian

AU - Kohama,Steven G.

AU - Hollister-Smith,Julie

AU - Ferguson,Betsy

AU - Woltjer,Randall L.

AU - Frederick,Meredith C.

AU - Pollaro,James

AU - Rooney,William D.

AU - Sherman,Larry S.

AU - Bourdette,Dennis N.

AU - Wong,Scott W.

PY - 2016/2/15

Y1 - 2016/2/15

N2 - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

AB - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

KW - Demyelination

KW - Inflammatory

KW - Interleukin 17 (IL-17)

KW - Intrathecal IgG

KW - Magnetic resonance imaging (MRI)

KW - Th1

KW - Th17

UR - http://www.scopus.com/inward/record.url?scp=84959353630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959353630&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2015.11.026

DO - 10.1016/j.jneuroim.2015.11.026

M3 - Article

VL - 291

SP - 1

EP - 10

JO - Journal of Neuroimmunology

T2 - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -