Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair, Minsha Manoharan, Stephanie D. Rawlings-Rhea, Ian Tagge, Steven G. Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L. Woltjer, Meredith C. Frederick, James Pollaro, William D. Rooney, Larry S. Sherman, Dennis N. Bourdette, Scott W. Wong

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume291
DOIs
StatePublished - Feb 15 2016

Keywords

  • Demyelination
  • Inflammatory
  • Interleukin 17 (IL-17)
  • Intrathecal IgG
  • Magnetic resonance imaging (MRI)
  • Th1
  • Th17

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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