TY - JOUR
T1 - Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis
AU - Blair, Tiffany C.
AU - Manoharan, Minsha
AU - Rawlings-Rhea, Stephanie D.
AU - Tagge, Ian
AU - Kohama, Steven G.
AU - Hollister-Smith, Julie
AU - Ferguson, Betsy
AU - Woltjer, Randall L.
AU - Frederick, Meredith C.
AU - Pollaro, James
AU - Rooney, William D.
AU - Sherman, Larry S.
AU - Bourdette, Dennis N.
AU - Wong, Scott W.
N1 - Funding Information:
The authors thank the dedicated animal care staff at the ONPRC for the humane treatment of the animals exhibiting JME, the Japanese Macaque Resource for support and Ms. Kristin Fitzpatrick and Ms. Lori Boshears for proof reading. This research was supported by a United States Department of Defense grant (W81XWH-09-1-0276) (LSS, BF, SGK, WDR, and SWW), a National Institutes of Health grant (P51OD011092-54) (BF, SGK, LSS and SWW), a Sylvia Lawry Fellowship from the National MS Society (MCF), and support from the Laura Fund for Multiple Sclerosis Research (DNB and SWW).
Funding Information:
The authors thank the dedicated animal care staff at the ONPRC for the humane treatment of the animals exhibiting JME, the Japanese Macaque Resource for support and Ms. Kristin Fitzpatrick and Ms. Lori Boshears for proof reading. This research was supported by a United States Department of Defense grant ( W81XWH-09-1-0276 ) (LSS, BF, SGK, WDR, and SWW), a National Institutes of Health grant ( P51OD011092-54 ) (BF, SGK, LSS and SWW), a Sylvia Lawry Fellowship from the National MS Society (MCF) , and support from the Laura Fund for Multiple Sclerosis Research (DNB and SWW).
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
AB - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
KW - Demyelination
KW - Inflammatory
KW - Interleukin 17 (IL-17)
KW - Intrathecal IgG
KW - Magnetic resonance imaging (MRI)
KW - Th1
KW - Th17
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U2 - 10.1016/j.jneuroim.2015.11.026
DO - 10.1016/j.jneuroim.2015.11.026
M3 - Article
C2 - 26857488
AN - SCOPUS:84959353630
VL - 291
SP - 1
EP - 10
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -