Abstract
Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
| Language | English (US) |
|---|---|
| Pages | 1-10 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 291 |
| DOIs | |
| State | Published - Feb 15 2016 |
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Keywords
- Demyelination
- Inflammatory
- Interleukin 17 (IL-17)
- Intrathecal IgG
- Magnetic resonance imaging (MRI)
- Th1
- Th17
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. / Blair, Tiffany C.; Manoharan, Minsha; Rawlings-Rhea, Stephanie D.; Tagge, Ian; Kohama, Steven G.; Hollister-Smith, Julie; Ferguson, Betsy; Woltjer, Randall L.; Frederick, Meredith C.; Pollaro, James; Rooney, William D.; Sherman, Larry S.; Bourdette, Dennis N.; Wong, Scott W.
In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 1-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis
AU - Blair,Tiffany C.
AU - Manoharan,Minsha
AU - Rawlings-Rhea,Stephanie D.
AU - Tagge,Ian
AU - Kohama,Steven G.
AU - Hollister-Smith,Julie
AU - Ferguson,Betsy
AU - Woltjer,Randall L.
AU - Frederick,Meredith C.
AU - Pollaro,James
AU - Rooney,William D.
AU - Sherman,Larry S.
AU - Bourdette,Dennis N.
AU - Wong,Scott W.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
AB - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
KW - Demyelination
KW - Inflammatory
KW - Interleukin 17 (IL-17)
KW - Intrathecal IgG
KW - Magnetic resonance imaging (MRI)
KW - Th1
KW - Th17
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UR - http://www.scopus.com/inward/citedby.url?scp=84959353630&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2015.11.026
DO - 10.1016/j.jneuroim.2015.11.026
M3 - Article
VL - 291
SP - 1
EP - 10
JO - Journal of Neuroimmunology
T2 - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -