Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair; Minsha Manoharan; Stephanie D. Rawlings-Rhea; Ian Tagge; Steven G. Kohama; Julie Hollister-Smith; Betsy Ferguson; Randall L. Woltjer; Meredith C. Frederick; James Pollaro; William D. Rooney; Larry S. Sherman; Dennis N. Bourdette; Scott W. Wong

doi:10.1016/j.jneuroim.2015.11.026

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair, Minsha Manoharan, Stephanie D. Rawlings-Rhea, Ian Tagge, Steven G. Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L. Woltjer, Meredith C. Frederick, James Pollaro, William D. Rooney, Larry S. Sherman, Dennis N. Bourdette, Scott W. Wong

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T₂-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	291
DOIs	https://doi.org/10.1016/j.jneuroim.2015.11.026
State	Published - Feb 15 2016

Keywords

Demyelination
Inflammatory
Interleukin 17 (IL-17)
Intrathecal IgG
Magnetic resonance imaging (MRI)
Th1
Th17

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Blair, T. C., Manoharan, M., Rawlings-Rhea, S. D., Tagge, I., Kohama, S. G., Hollister-Smith, J., Ferguson, B., Woltjer, R. L., Frederick, M. C., Pollaro, J., Rooney, W. D., Sherman, L. S., Bourdette, D. N., & Wong, S. W. (2016). Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. Journal of Neuroimmunology, 291, 1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. / Blair, Tiffany C.; Manoharan, Minsha; Rawlings-Rhea, Stephanie D.; Tagge, Ian; Kohama, Steven G.; Hollister-Smith, Julie; Ferguson, Betsy ; Woltjer, Randall L.; Frederick, Meredith C.; Pollaro, James; Rooney, William D.; Sherman, Larry S.; Bourdette, Dennis N.; Wong, Scott W.

In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 1-10.

Research output: Contribution to journal › Article

Blair, TC, Manoharan, M, Rawlings-Rhea, SD, Tagge, I, Kohama, SG, Hollister-Smith, J, Ferguson, B , Woltjer, RL, Frederick, MC, Pollaro, J, Rooney, WD , Sherman, LS , Bourdette, DN & Wong, SW 2016, 'Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis', Journal of Neuroimmunology, vol. 291, pp. 1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026

Blair, Tiffany C. ; Manoharan, Minsha ; Rawlings-Rhea, Stephanie D. ; Tagge, Ian ; Kohama, Steven G. ; Hollister-Smith, Julie ; Ferguson, Betsy ; Woltjer, Randall L. ; Frederick, Meredith C. ; Pollaro, James ; Rooney, William D. ; Sherman, Larry S. ; Bourdette, Dennis N. ; Wong, Scott W. / Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. In: Journal of Neuroimmunology. 2016 ; Vol. 291. pp. 1-10.

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abstract = "Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.",

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