Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair, Minsha Manoharan, Stephanie D. Rawlings-Rhea, Ian Tagge, Steven Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall (Randy) Woltjer, Meredith C. Frederick, James Pollaro, William Rooney, Lawrence (Larry) Sherman, Dennis Bourdette, Scott Wong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume291
DOIs
StatePublished - Feb 15 2016

Fingerprint

Encephalomyelitis
Macaca
Multiple Sclerosis
Central Nervous System
T-Lymphocytes
Interleukin-17
Immune System Diseases
Gadolinium
Demyelinating Diseases
Primates
Magnetic Resonance Imaging
Phenotype
Research

Keywords

  • Demyelination
  • Inflammatory
  • Interleukin 17 (IL-17)
  • Intrathecal IgG
  • Magnetic resonance imaging (MRI)
  • Th1
  • Th17

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Blair, T. C., Manoharan, M., Rawlings-Rhea, S. D., Tagge, I., Kohama, S., Hollister-Smith, J., ... Wong, S. (2016). Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. Journal of Neuroimmunology, 291, 1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. / Blair, Tiffany C.; Manoharan, Minsha; Rawlings-Rhea, Stephanie D.; Tagge, Ian; Kohama, Steven; Hollister-Smith, Julie; Ferguson, Betsy; Woltjer, Randall (Randy); Frederick, Meredith C.; Pollaro, James; Rooney, William; Sherman, Lawrence (Larry); Bourdette, Dennis; Wong, Scott.

In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 1-10.

Research output: Contribution to journalArticle

Blair TC, Manoharan M, Rawlings-Rhea SD, Tagge I, Kohama S, Hollister-Smith J et al. Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. Journal of Neuroimmunology. 2016 Feb 15;291:1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026
Blair, Tiffany C. ; Manoharan, Minsha ; Rawlings-Rhea, Stephanie D. ; Tagge, Ian ; Kohama, Steven ; Hollister-Smith, Julie ; Ferguson, Betsy ; Woltjer, Randall (Randy) ; Frederick, Meredith C. ; Pollaro, James ; Rooney, William ; Sherman, Lawrence (Larry) ; Bourdette, Dennis ; Wong, Scott. / Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. In: Journal of Neuroimmunology. 2016 ; Vol. 291. pp. 1-10.
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