TY - JOUR
T1 - Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis
AU - Blair, Tiffany C.
AU - Manoharan, Minsha
AU - Rawlings-Rhea, Stephanie D.
AU - Tagge, Ian
AU - Kohama, Steven G.
AU - Hollister-Smith, Julie
AU - Ferguson, Betsy
AU - Woltjer, Randall L.
AU - Frederick, Meredith C.
AU - Pollaro, James
AU - Rooney, William D.
AU - Sherman, Larry S.
AU - Bourdette, Dennis N.
AU - Wong, Scott W.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
AB - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
KW - Demyelination
KW - Inflammatory
KW - Interleukin 17 (IL-17)
KW - Intrathecal IgG
KW - Magnetic resonance imaging (MRI)
KW - Th1
KW - Th17
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UR - http://www.scopus.com/inward/citedby.url?scp=84959353630&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2015.11.026
DO - 10.1016/j.jneuroim.2015.11.026
M3 - Article
C2 - 26857488
AN - SCOPUS:84959353630
SN - 0165-5728
VL - 291
SP - 1
EP - 10
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -