Immunolqcaljzation of fbroblast growth factor receptor (FGFR)-1 and 2 in joint tissue from rats with adjuvant arthritis

J. T. Rosenhaum, Z. Ou, W. D. Spangler, P. Ahmadi, Michael (Mike) Powers

Research output: Contribution to journalArticle

Abstract

Our previous studies have demonstrated an altered distribution of basic fibroblast growth factor (bFGF) in synovium from patients with rheumatoid arthritis and rats with adjuvant arthritis. To further elucidate the roles of bFGF in articular inflammation, we examined the distribution patterns of two high affinity receptors for bFGF, FGFR-1 and -2, in the arthritic joints of rats using immunohistochemistry. In normal joints, selective staining for both FGFRs was found to be mainly associated with lining synoviocytes and chondrocytes. In arthritic joint tissues, increased staining for both FGFRs was observed in lining and sublining synoviocytes. While staining for FGFR-2 was found only in the cytoplasm of fibroblast-like synoviocytes that exhibited hypertrophy and hyperplasia. staining for FGFR-1 was mainly seen in their nucleus. Paradoxically, increased staining for these FGFRs was also observed in areas with active osteogenesis. The overall staining patterns of these FGFRs is comparable to that of bFGF reported. These findings further implicate bFGF in the destructive arthropathy and suggest that the invasive growth of inflamed synovium may result from an exaggerated response to bFGF due to increased levels of FGFR-1 and -2.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number6
StatePublished - 1996

Fingerprint

fibroblast growth factor 2
Experimental Arthritis
Growth Factor Receptors
arthritis
Fibroblast Growth Factor 2
growth factors
adjuvants
Rats
Joints
Tissue
Staining and Labeling
receptors
rats
Synovial Membrane
Linings
Arthritis
rheumatoid arthritis
Joint Diseases
chondrocytes
Fibroblasts

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Immunolqcaljzation of fbroblast growth factor receptor (FGFR)-1 and 2 in joint tissue from rats with adjuvant arthritis. / Rosenhaum, J. T.; Ou, Z.; Spangler, W. D.; Ahmadi, P.; Powers, Michael (Mike).

In: FASEB Journal, Vol. 10, No. 6, 1996.

Research output: Contribution to journalArticle

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AU - Powers, Michael (Mike)

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