Immunological reactivity in dermatophytosis

JON M. HANIFIN, LEON F. RAY, WALTER C. LOBITZ

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Abstract

Patients with Trichophyton mentagrophytes and T. rubrum infections were compared in terms of cutaneous responses and in vitro lymphocyte reactivity to trichophytin and other antigens. Twelve out of fourteen T. mentagrophytes patients exhibited delayed cutaneous hypersensitivity to trichophytin. Most T. rubrum patients (thirty‐seven out of forty‐nine) lacked delayed reactions to trichophytin specifically, but these patients frequently manifested immediate weal reactions to this antigen. Positive lymphocyte responses correlated with the presence of delayed but not immediate cutaneous reactions. Serum from chronic T. rubrum patients failed to inhibit lymphocyte responses. Possible mechanisms for selective anergy in chronic T. rubrum patients are discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBritish Journal of Dermatology
Volume90
Issue number1
DOIs
StatePublished - Jan 1974

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ASJC Scopus subject areas

  • Dermatology

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