Immunological reactivity in dermatophytosis

Jon Hanifin, L. F. Ray, W. C. Lobitz

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Patients with Trichophyton mentagrophytes and T. rubrum infections were compared in terms of cutaneous responses and in vitro lymphocyte reactivity to trichophytin and other antigens. Twelve out of 14 T. mentagrophytes patients exhibited delayed cutaneous hypersensitivity to trichophytin specifically, but these patients frequently manifested immediate weal reactions to this antigen. Positive lymphocyte responses correlated with the presence of delayed but not immediate cutaneous reactions. Serum from chronic T. rubrum patients failed to inhibit lymphocyte responses. Possible mechanisms for selective anergy in chronic T. rubrum patients are discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBritish Journal of Dermatology
Volume90
Issue number1
StatePublished - 1974

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Tinea
Trichophytin
Lymphocytes
Skin
Antigens
Trichophyton
Delayed Hypersensitivity
Infection
Serum

ASJC Scopus subject areas

  • Dermatology

Cite this

Immunological reactivity in dermatophytosis. / Hanifin, Jon; Ray, L. F.; Lobitz, W. C.

In: British Journal of Dermatology, Vol. 90, No. 1, 1974, p. 1-8.

Research output: Contribution to journalArticle

Hanifin, J, Ray, LF & Lobitz, WC 1974, 'Immunological reactivity in dermatophytosis', British Journal of Dermatology, vol. 90, no. 1, pp. 1-8.
Hanifin, Jon ; Ray, L. F. ; Lobitz, W. C. / Immunological reactivity in dermatophytosis. In: British Journal of Dermatology. 1974 ; Vol. 90, No. 1. pp. 1-8.
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