Immunological expression of gangliosides in multiple sclerosis and in a demyelinating model disease in rabbits.

B. A. Sela, Halina Offner, G. Konat, V. Lev-Ram, O. Cohen, I. R. Cohen

Research output: Contribution to journalArticle

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Abstract

Accumulating evidence suggests that the process of demyelination in MS might involve an autoimmune response to one or more myelin components. A combination of myelin basic protein and myelin haptens was considered as possibly enhancing a cellular or humoral autoimmune reaction in MS. In line with this motion we have used an in-vitro E-rosette assay that correlates with in-vivo delayed hypersensitivity to demonstrate specific immunologic sensitivity of lymphocytes from MS patients to polysialogangliosides. A recent report that only lymphocytes from patients in relapse, but not in remission, are primed by gangliosides, underscores the relevance of the antigenic expression of gangliosides during the active pathological phase of the disease. The antigenic capacity of gangliosides to induce upon immunization a neurological disorder featured by demyelination in the CNS was demonstrated in rabbits. This and previous reports on the induction of peripheral demyelination in rabbits immunized with gangliosides will be further analyzed to gain insight on the possible role of these myelin lipid components as targets for an autoimmune mechanism in MS.

Original languageEnglish (US)
Pages (from-to)441-453
Number of pages13
JournalAdvances in Experimental Medicine and Biology
Volume174
StatePublished - 1984
Externally publishedYes

Fingerprint

Gangliosides
Demyelinating Diseases
Multiple Sclerosis
Myelin Sheath
Rabbits
Lymphocytes
Immunization
Myelin Basic Protein
Haptens
Delayed Hypersensitivity
Nervous System Diseases
Autoimmunity
Assays
Lipids
Recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Immunological expression of gangliosides in multiple sclerosis and in a demyelinating model disease in rabbits. / Sela, B. A.; Offner, Halina; Konat, G.; Lev-Ram, V.; Cohen, O.; Cohen, I. R.

In: Advances in Experimental Medicine and Biology, Vol. 174, 1984, p. 441-453.

Research output: Contribution to journalArticle

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