Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats

L. Munson, L. A. Harrenstien, A. E. Acton, P. A. Graham, L. M. Chassy, J. F. Kirkpatrick

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A vaccine of native PZP with Freund's adjuvant has been widely used in zoo and wild ungulates, but safety in felids has not been evaluated. General health, immune response, and ovarian histology were assessed in five domestic cats vaccinated with PZP-Freund's and five cats given Freund's adjuvant alone. Peak antibody titers occurred 3 weeks after the third vaccination, and no ovarian lesions were present 6 months after vaccination. Seven cats developed extensive granulomatous reactions at injection sites, lymph nodes, and multiple visceral organs including lungs and brain. Persistent hypercalcemia and compromised renal function occurred in three cats with elevated serum calcitriol of probable macrophage origin. One cat died from an injection site sarcoma. Because of these severe adverse reactions, Freund's adjuvant is contraindicated in cats, and other adjuvants for PZP vaccines should be tested in cats for adverse reactions before use.

Original languageEnglish (US)
Pages (from-to)5646-5654
Number of pages9
JournalVaccine
Volume23
Issue number48-49
DOIs
StatePublished - Dec 1 2005

Keywords

  • Freund's adjuvant
  • Hypercalcemia
  • Porcine zona pellucida

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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