Immunologic privilege in the central nervous system and the blood-brain barrier

Leslie Muldoon, Jorge I. Alvarez, David J. Begley, Ruben J. Boado, Gregory J. Del Zoppo, Nancy Doolittle, Britta Engelhardt, John M. Hallenbeck, Russell R. Lonser, John R. Ohlfest, Alexandre Prat, Maurizio Scarpa, Richard J. Smeyne, Lester R. Drewes, Edward Neuwelt

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The brain is in many ways an immunologically and pharmacologically privileged site. The blood-brain barrier (BBB) of the cerebrovascular endothelium and its participation in the complex structure of the neurovascular unit (NVU) restrict access of immune cells and immune mediators to the central nervous system (CNS). In pathologic conditions, very well-organized immunologic responses can develop within the CNS, raising important questions about the real nature and the intrinsic and extrinsic regulation of this immune privilege. We assess the interactions of immune cells and immune mediators with the BBB and NVU in neurologic disease, cerebrovascular disease, and intracerebral tumors. The goals of this review are to outline key scientific advances and the status of the science central to both the neuroinflammation and CNS barriers fields, and highlight the opportunities and priorities in advancing brain barriers research in the context of the larger immunology and neuroscience disciplines. This review article was developed from reports presented at the 2011 Annual Blood-Brain Barrier Consortium Meeting.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Blood-Brain Barrier
Central Nervous System
Cerebrovascular Disorders
Brain
Neurosciences
Allergy and Immunology
Nervous System Diseases
Cell Communication
Endothelium
Research
Neoplasms

Keywords

  • blood-brain barrier
  • multiple sclerosis
  • neuroimaging
  • neuroinflammation
  • neurovascular unit

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Immunologic privilege in the central nervous system and the blood-brain barrier. / Muldoon, Leslie; Alvarez, Jorge I.; Begley, David J.; Boado, Ruben J.; Del Zoppo, Gregory J.; Doolittle, Nancy; Engelhardt, Britta; Hallenbeck, John M.; Lonser, Russell R.; Ohlfest, John R.; Prat, Alexandre; Scarpa, Maurizio; Smeyne, Richard J.; Drewes, Lester R.; Neuwelt, Edward.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No. 1, 01.2013, p. 13-21.

Research output: Contribution to journalArticle

Muldoon, L, Alvarez, JI, Begley, DJ, Boado, RJ, Del Zoppo, GJ, Doolittle, N, Engelhardt, B, Hallenbeck, JM, Lonser, RR, Ohlfest, JR, Prat, A, Scarpa, M, Smeyne, RJ, Drewes, LR & Neuwelt, E 2013, 'Immunologic privilege in the central nervous system and the blood-brain barrier', Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 1, pp. 13-21. https://doi.org/10.1038/jcbfm.2012.153
Muldoon, Leslie ; Alvarez, Jorge I. ; Begley, David J. ; Boado, Ruben J. ; Del Zoppo, Gregory J. ; Doolittle, Nancy ; Engelhardt, Britta ; Hallenbeck, John M. ; Lonser, Russell R. ; Ohlfest, John R. ; Prat, Alexandre ; Scarpa, Maurizio ; Smeyne, Richard J. ; Drewes, Lester R. ; Neuwelt, Edward. / Immunologic privilege in the central nervous system and the blood-brain barrier. In: Journal of Cerebral Blood Flow and Metabolism. 2013 ; Vol. 33, No. 1. pp. 13-21.
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